Formulation and Evaluation of Nanoemulsion using Tazarotene and Curcumin

Aims: To formulate and evaluate nanoemulsion of Tazarotene and Curcumin Study Design: Ultrsonication Methods. Place and Duration of Study, Sample: Swami Dayanand Postgraduate Institute of Pharmaceuticals Sciences, University of Health Sciences, Rohtak; 2020-2021 Methodology: Oleic acid, tween 80, and propylene glycol were selected as oil, surfactant, and co-surfactant, respectively. The ratio of oil: surfactant: co-surfactant was selected based on a ternary phase diagram using the aqueous titration method. The selected ratio was employed to develop eight formulations of Tazarotene-curcumin by ultra-sonication. The formulations (F1-F8) were characterized using several physicochemical methods like pH, viscosity, particle size distribution, zeta potential, drug content, and in vitro release. The optimized formulation was selected based on the results of characterization. Results: The formulations (F1-F8) were formulated by using the ultrasonication (high energy) method. The optimized formulation possessed particle size 121, 0.382 PDI, and -20.1 zeta potential. The in vitro release of F6 was found to be 90.9 ± 3.1 at 24 hours. It also passed the thermodynamic stability tests. Conclusion: The current investigations conclude that Tazarotene-curcumin nanoemulsion can be used as an alternative to the oral route of tazarotene and is also useful in reducing the adverse effects associated with oral. The physicochemical evaluation of the formulation showed that the nanoemulsion had the necessary properties for a topical formulation.