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Synthesis and characterization of F127-Glu@ZnO nanogel material for cisplatin drug delivery application
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A novel F127-Glu@ZnO nanogel was synthesized for cisplatin delivery by functionalizing ZnO nanoparticles with L-glutamic acid (Glu) and grafting Pluronic onto Glu via urethane linkages. FT-IR and ¹H-NMR confirmed successful synthesis, while TEM characterized morphology. The nanogel exhibited pH-responsive drug release, accelerating cisplatin release in acidic environments. This suggests its potential as a smart drug delivery system for improving therapeutic efficacy and reducing side effects in cancer treatment.
Academy of Military Science and Technology
Title: Synthesis and characterization of F127-Glu@ZnO nanogel material for cisplatin drug delivery application
Description:
A novel F127-Glu@ZnO nanogel was synthesized for cisplatin delivery by functionalizing ZnO nanoparticles with L-glutamic acid (Glu) and grafting Pluronic onto Glu via urethane linkages.
FT-IR and ¹H-NMR confirmed successful synthesis, while TEM characterized morphology.
The nanogel exhibited pH-responsive drug release, accelerating cisplatin release in acidic environments.
This suggests its potential as a smart drug delivery system for improving therapeutic efficacy and reducing side effects in cancer treatment.
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