Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Solubilization of hemoglobin S by other hemoglobins.
View through CrossRef
The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the order A > A2 > F. The solubility of Hb S is substantially increased by the other hemoglobins, especially by Hb F, which would account for its antisickling effect. It appears that the excluded volume effect of the other hemoglobin on Hb S is largely counterbalanced by the solubilizing effect arising from the interaction between the two hemoglobins in solution. The ability of hybrid hemoglobins to gel was demonstrated directly with tetramers in which alpha beta s dimers were covalently linked to alpha beta A, alpha delta A2, and alpha gamma F dimers.
Proceedings of the National Academy of Sciences
Title: Solubilization of hemoglobin S by other hemoglobins.
Description:
The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation.
In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the order A > A2 > F.
The solubility of Hb S is substantially increased by the other hemoglobins, especially by Hb F, which would account for its antisickling effect.
It appears that the excluded volume effect of the other hemoglobin on Hb S is largely counterbalanced by the solubilizing effect arising from the interaction between the two hemoglobins in solution.
The ability of hybrid hemoglobins to gel was demonstrated directly with tetramers in which alpha beta s dimers were covalently linked to alpha beta A, alpha delta A2, and alpha gamma F dimers.
Related Results
Studies on Abnormal Hemoglobins
Studies on Abnormal Hemoglobins
Abstract
1. When sufficiently concentrated sickle cell hemoglobin containing solutions are exposed to a constant stream of CO2 gas, the hemolysates gel. This gelling...
Chemical Characterization of Three Hemoglobins G
Chemical Characterization of Three Hemoglobins G
Abstract
Three abnormal hemoglobins identified as G by their electrophoretic mobility and performance on resin chromatography have been discovered in three healthy u...
The interplay between molten globules and heme disassociation defines human hemoglobin disassembly
The interplay between molten globules and heme disassociation defines human hemoglobin disassembly
AbstractHemoglobin functions as an oxygen transport protein, with each subunit containing a heme cofactor. We have developed a global disassembly model for human hemoglobin, linkin...
Role of Rhizosphere Soil Microbes in Adapting Ramie (Boehmeria nivea L.) Plants to Poor Soil Conditions through N-Fixing and P-Solubilization
Role of Rhizosphere Soil Microbes in Adapting Ramie (Boehmeria nivea L.) Plants to Poor Soil Conditions through N-Fixing and P-Solubilization
The N-fixing and P-solubilization functions of soil microbes play a vital role in plant adaptation to nutrient-deficiency conditions. However, their exact roles toward the adaptati...
Studies on Abnormal Hemoglobins
Studies on Abnormal Hemoglobins
Abstract
1. By exposing hemoglobin solutions to an alkaline reagent at a pH of 12.7 it was found that normal pigment is completely denatured within one minute. Thus ...
Early hemoglobin status is predictive of outcomes and long-term mortality of sepsis
Early hemoglobin status is predictive of outcomes and long-term mortality of sepsis
Abstract
Background: Hemoglobin change plays a critical role in progress of sepsis. However, the contribution of hemoglobin change to outcomes of patients with sepsis is st...
Hemoglobins, haptoglobins, and transferrins in indigenous populations of Kenya
Hemoglobins, haptoglobins, and transferrins in indigenous populations of Kenya
AbstractHemoglobin, haptoglobin, and transferrin phenotypes were determined by means of starchâgel electrophoresis for a sample of 226 Kenya hospital patients. Allele frequencies w...
Associations of glycated hemoglobin with hemoglobin levels and erythrocyte parameters
Associations of glycated hemoglobin with hemoglobin levels and erythrocyte parameters
Background. In patients with diabetes mellitus, pathologic changes occur in multiple organs and systems, the pathogenesis of which involves inflammatory reactions. The chronic infl...