Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Comb‐Shaped Glycopolymer/Peptide Bioconjugates by Combination of RAFT Polymerization and Thiol‐Ene “Click” Chemistry
View through CrossRef
AbstractComb‐shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate‐functional block glycocopolymers via thiol‐ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self‐assembles to sugar‐installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH‐responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH‐responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery. magnified image
Title: Comb‐Shaped Glycopolymer/Peptide Bioconjugates by Combination of RAFT Polymerization and Thiol‐Ene “Click” Chemistry
Description:
AbstractComb‐shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate‐functional block glycocopolymers via thiol‐ene click chemistry.
In aqueous solution, the glycopolymer/GSH bioconjugate self‐assembles to sugar‐installed spherical micelles.
The size of micelles decreases with increasing pH, demonstrating pH‐responsive character.
The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.
43.
The micelles show a specific interaction with the protein Concanavalin A.
At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade.
These pH‐responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
magnified image.
Related Results
Effect of ground subsidence on piled raft foundation
Effect of ground subsidence on piled raft foundation
Extensive researches for piled rafts have been performed but the evaluation of their behavior in ground subsidence condition is still a challenge. In this study, centrifugal tests ...
A Versatile Heteroatom Nucleophile Hub enabling divergent Thiol and Amine Bioconjugate Synthesis
A Versatile Heteroatom Nucleophile Hub enabling divergent Thiol and Amine Bioconjugate Synthesis
Bioconjugates have widespread applications in biologically relevant fields and are typically synthesized through the coupling of naturally abundant nucleophiles, such as thiol and ...
Design and analysis of dual-curing systems
Design and analysis of dual-curing systems
Dual-curing processing is a method to prepare thermoset materials through two polymerization reactions carried out
simultaneously or sequentially. In these processes, a firm under...
Thiol reductive stress activates the hypoxia response pathway
Thiol reductive stress activates the hypoxia response pathway
AbstractOwing to their capability to disrupt the oxidative protein folding environment in the endoplasmic reticulum (ER), thiol antioxidants such as dithiothreitol (DTT) are used a...
Anemia Is Inversely Associated with Serum C-Peptide Concentrations in Patients with Type 2 Diabetes
Anemia Is Inversely Associated with Serum C-Peptide Concentrations in Patients with Type 2 Diabetes
Results: The aim of the study was to investigate the relationship between anemia and serum C-peptide concentrations in Korean patients with type 2 diabetes. A total of 1,300 subjec...
X-Yne Click Polymerization
X-Yne Click Polymerization
Alkyne-based click polymerizations have been nurtured into a powerful synthetic technique for the synthesis of new polymers with advanced structures and versatile functionalities. ...
Preparation of hyperbranched polymers by atom transfer radical polymerization
Preparation of hyperbranched polymers by atom transfer radical polymerization
AbstractA cheap acrylic AB* monomer, 2‐(2‐chloroacetyloxy)‐isopropyl acrylate (CAIPA), was prepared from 2‐hydroxyisopropyl acrylate with chloroacetyl chloride in the presence of t...
Three new Nearctic genera of oak cynipid gall wasps (Hymenoptera: Cynipidae: Cynipini): Burnettweldia Pujade-Villar, Melika & Nicholls, Nichollsiella Melika, Pujade-Villar & Stone, Disholandricus Melika, Pujade-Villar & Nicholls; a
Three new Nearctic genera of oak cynipid gall wasps (Hymenoptera: Cynipidae: Cynipini): Burnettweldia Pujade-Villar, Melika & Nicholls, Nichollsiella Melika, Pujade-Villar & Stone, Disholandricus Melika, Pujade-Villar & Nicholls; a
We describe three new genera of cynipid oak gall wasps from the Nearctic: Burnettweldia Pujade-Villar, Melika & Nicholls, gen. nov., Nichollsiella Melika, Pujade-Villar & S...