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Comb‐Shaped Glycopolymer/Peptide Bioconjugates by Combination of RAFT Polymerization and Thiol‐Ene “Click” Chemistry
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AbstractComb‐shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate‐functional block glycocopolymers via thiol‐ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self‐assembles to sugar‐installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH‐responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH‐responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery. magnified image
Title: Comb‐Shaped Glycopolymer/Peptide Bioconjugates by Combination of RAFT Polymerization and Thiol‐Ene “Click” Chemistry
Description:
AbstractComb‐shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate‐functional block glycocopolymers via thiol‐ene click chemistry.
In aqueous solution, the glycopolymer/GSH bioconjugate self‐assembles to sugar‐installed spherical micelles.
The size of micelles decreases with increasing pH, demonstrating pH‐responsive character.
The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.
43.
The micelles show a specific interaction with the protein Concanavalin A.
At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade.
These pH‐responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
magnified image.
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