Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Expression of syndecan‐1 is a sensitive marker for cutaneous plasmacytoma
View through CrossRef
Background: Cutaneous plasmacytoma is a well‐recognized, yet infrequent, occurrence in multiple myeloma (MM). There are limitations in the morphologic assessment, and as such, the diagnosis presents some difficulty, particularly with the plasmablastic type.Methods: Pathology reports of 2357 patients with a diagnosis of MM were reviewed. Twenty patients yielded a total of 25 plasmacytomas, 10 of which were analyzed for syndecan‐1 immunoreactivity. Bartl grade of bone marrow and cutaneous plasmacytoma was compared and immunoglobulin secretory status of the patients was assessed.Results: The incidence of cutaneous plasmacytoma was found to be 1 in 118 patients with MM. Immunoglobulin secretion was found to be predominantly IgG. There was a trend for the plasmacytoma Bartl grade to be equal to or greater than that of the corresponding bone marrow Bartl grade, suggesting a more aggressive phenotype in the metastatic lesion.Conclusion: Syndecan‐1 was found to be a sensitive marker for plasmacytomas, independent of cytologic differentiation.
Title: Expression of syndecan‐1 is a sensitive marker for cutaneous plasmacytoma
Description:
Background: Cutaneous plasmacytoma is a well‐recognized, yet infrequent, occurrence in multiple myeloma (MM).
There are limitations in the morphologic assessment, and as such, the diagnosis presents some difficulty, particularly with the plasmablastic type.
Methods: Pathology reports of 2357 patients with a diagnosis of MM were reviewed.
Twenty patients yielded a total of 25 plasmacytomas, 10 of which were analyzed for syndecan‐1 immunoreactivity.
Bartl grade of bone marrow and cutaneous plasmacytoma was compared and immunoglobulin secretory status of the patients was assessed.
Results: The incidence of cutaneous plasmacytoma was found to be 1 in 118 patients with MM.
Immunoglobulin secretion was found to be predominantly IgG.
There was a trend for the plasmacytoma Bartl grade to be equal to or greater than that of the corresponding bone marrow Bartl grade, suggesting a more aggressive phenotype in the metastatic lesion.
Conclusion: Syndecan‐1 was found to be a sensitive marker for plasmacytomas, independent of cytologic differentiation.
Related Results
1621 Extramedullary Plasmacytoma of the Colon
1621 Extramedullary Plasmacytoma of the Colon
INTRODUCTION:
Plasma cell tumors can be categorized into multiple myeloma or plasmacytomas. Plasmacytoma is the proliferation of neoplastic monoclonal plasma cells in s...
Elevated Serum Syndecan-1 Levels Are Associated with Obesity-Related Complications in Children
Elevated Serum Syndecan-1 Levels Are Associated with Obesity-Related Complications in Children
Background: Syndecan-1 plays a crucial role in cell differentiation, growth, adhesion, wound healing, and inflammatory processes. It has been linked to obesity, particularly overwe...
Different Heparan Sulfate Proteoglycans Serve asCellular Receptors for HumanPapillomaviruses
Different Heparan Sulfate Proteoglycans Serve asCellular Receptors for HumanPapillomaviruses
ABSTRACT
Papillomaviruses
replicate in stratified epithelia of skin and mucosa. Infection with
certain human papillomavirus (HPV) types is the main cause of
anogenital ne...
Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation
Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation
The cellular mechanisms responsible for synaptic plasticity involve interactions between neurons and the extracellular matrix. Heparan sulfates (HSs) constitute a group of glycosam...
Spectrum of cutaneous lupus erythematosus in South Africans with systemic lupus erythematosus
Spectrum of cutaneous lupus erythematosus in South Africans with systemic lupus erythematosus
Background Cutaneous involvement is very common in systemic lupus erythematosus. We describe the prevalence and spectrum of lupus-specific (cutaneous lupus erythematosus) and non-s...
A Study on the Difference in Aging Characteristics of Sensitive and Non‐Sensitive Skin
A Study on the Difference in Aging Characteristics of Sensitive and Non‐Sensitive Skin
ABSTRACTBackgroundAccording to Euromonitor and T Mall data statistics from 2017 to 2022, the Chinese market for sensitive skin (SS) skincare is growing by 20% every year, and anti‐...
Solitary Plasmacytoma of the Cecum and the Ascending Colon: Surgical Resection as a Treatment Modality
Solitary Plasmacytoma of the Cecum and the Ascending Colon: Surgical Resection as a Treatment Modality
Colonic solitary plasmacytoma is a rare disease, with few reports occurring in the literature. Solitary plasmacytoma is defined as a plasma cell tumour with no evidence of bone mar...
Extramedullary Plasmacytoma of the Gallbladder Detected on Fluorine 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
Extramedullary Plasmacytoma of the Gallbladder Detected on Fluorine 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
Extramedullary plasmacytoma is rare in patients with diagnosed multiple myeloma. Soft tissue plasmacytoma of the gallbladder is particularly uncommon and has been described in only...