Comparison of the Effects of Single– and Multiple– Visit Root Canal Therapy on Oral Stress Damage and Nutritional Status in Patients with Endodontic Disease

Clinically, endodontic disease is the most common oral disease, with root canal therapy being the mainstay of treatment at present. However, the choice between single-visit versus multiple-visit root canal therapy remains controversial. In this study, we compared the clinical outcomes of patients who underwent single– or multiple–visit root canal therapy and found no difference in the overall response rate between the two groups. Single–visit root canal therapy led to markedly reduced scores on the gingival bleeding index and plaque index, a lower incidence of adverse reactions, milder inflammatory reactions, and less oxidative stress damage, indicating a higher clinical safety profile compared to multiple-visit root canal therapy. Additionally, the nutritional status of patients was better after single-visit root canal therapy. Therefore, single–visit root canal therapy demonstrates greater clinical utility for the treatment of endodontic disease.