Cardiac Adverse Events Post Vaccination

Some vaccinees experience cardiac adverse events (AEs) following immunization (AEFI). These AEs include both background events and for some vaccines, vaccine associated AEs. A small subset of AEs experienced by vaccinees are reported to the United States Vaccine Adverse Event Reporting System (VAERS). Herein, VAERS was retrospectively examined to identify cardiac AEFI associations. VAERS data was examined by vaccine type, vaccine source, vaccinee gender, and vaccinee age for infants. Multiple cardiac AEFI association patterns were detected: bradycardia and cardiac arrest for infants age 0, arrhythmia for COVID-19 and HPV vaccines, atrial fibrillation for COVID-19, influenza, and RSV vaccines, myocarditis and pericarditis for anthrax, COVID-19, smallpox, and typhoid vaccines, and chest discomfort, chest pain, palpitations, and tachycardia for multiple vaccines. Gender differences were observed for both myocarditis and palpitation AEFIs. Significant differences in bradycardia and cardiac arrest AEFI normalized frequencies were observed for the same infant vaccines from different manufacturers, suggesting possible manufacturing contaminants (e.g., endotoxins, DNA) as candidate causative components. Conclusions: Infant bradycardia and cardiac arrest AEFIs could be reduced by either delaying specific vaccines until infants are 1 year of age, selecting alternative vaccine options, or reduction or elimination of causative components (e.g., aluminium adjuvant, manufacturing contaminates, etc.). Both male and female myocarditis AEs can be modelled by mathematical age relationships for COVID-19 vaccines that may also apply to additional vaccines, suggesting possible shared etiologies. Multiple vaccines were observed with correlated cardiac AEFIs association signals for chest discomfort, chest pain, palpitations, and tachycardia; elevated histamine levels may contribute to the etiologies of these AEFIs.