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Spectrophotometric Determination of Piperazine in Pharmaceutical Preparations
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Abstract
A solution of piperazine or its salts is heated with 2,6-dichloroquinonechlorimide, and the color produced is measured at 525 nm to obtain the concentration of piperazine. The color developed obeys Beer’s law in the concentration range of 6.4–51.2 μg piperazine/ml. The results of the proposed method agree with those of the official methods within ± 1.0% for piperazine and its salts and ± 2.0% for formulations. The method is rapid and precise and gives reproducible results. It is suitable for the analytical control of piperazine or its salts and their formulations.
Oxford University Press (OUP)
Title: Spectrophotometric Determination of Piperazine in Pharmaceutical Preparations
Description:
Abstract
A solution of piperazine or its salts is heated with 2,6-dichloroquinonechlorimide, and the color produced is measured at 525 nm to obtain the concentration of piperazine.
The color developed obeys Beer’s law in the concentration range of 6.
4–51.
2 μg piperazine/ml.
The results of the proposed method agree with those of the official methods within ± 1.
0% for piperazine and its salts and ± 2.
0% for formulations.
The method is rapid and precise and gives reproducible results.
It is suitable for the analytical control of piperazine or its salts and their formulations.
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