Effect of Intra-socket Application of Hyaluronic Acid Gel on Soft and Hard Tissue Healing Following Impacted Mandibular Third Molars Extraction(a Randomized Controlled Clinical Trial)

Abstract Background One of the most frequent dental operations is the surgical extraction of an impacted third molar. The study aimed to evaluate the impact of the intra-socket application of 0.8% hyaluronic acid (HA) gel on hard & soft tissue healing after surgical removal of the impacted 3rd molar. Objective Materials and methods This randomized controlled clinical study included thirty patients aged from 21–36 years who were scheduled for surgical removal of impacted mandibular third molar. 0.8% hyaluronic acid gel (HA group) was applied immediately after surgery in the intra-socket of 15 patients, and nothing (No HA group) was applied to the socket of the other 15 patients. Soft and hard tissue healing was assessed after extraction on the third, seventh, and fourteenth day. Results The soft tissue healing index was significantly better (very good or excellent) in the HA group compared with no HA group after fourteen days postoperative (p < .001). Also, the percentage increase of bone density in the HA group was statistically significantly higher after two months than in the no HA group ((p < .001) Conclusion Hyaluronic acid 0.8% gel application improves soft tissue healing and bone density healing following surgical extraction of the mandibular third molar. It could be considered a valuable material for improving bone healing and soft tissue. Trial registration The trial is retrospectively registered at the Pan African Clinical Trial Registry with the identification number for the registry PACTR202407576478340.