Trend in incidence and mortality of cancer, a high -risk area in Gansu province: Analysis of the 2010 to 2018 in Gansu Central Cancer Registry

Abstract Background: The incidence and mortality of cancer in Gansu Province remain high, especially the digestive system tumors have long been in the top 5, and there is a rising trend. This paper uses the cancer registration data in Gansu Province from 2010 to 2018 to analyze the trend of trend changes, and provides information for the government basis for decision-making.Methods: The registration data of cancer incidence, death and population data reported by 23 cancer registration sites in Gansu Province in 2021 were collected, and the data of 15 registration sites met the quality control standards. The incidence (mortality) rate, age-standardized incidence(mortality) rate, cumulative rate(0~74 years old) were calculated according to gender, areas(urban and rural) and age groups. The age-standardized rate was calculated and adjusted by Chinese standard population in 2000(ASIRC, ASMRC) and world standard(Segi’s) population(ASIRW, ASMRW), respectively. Joinpoint Regression Program was used to estimate the annual percentage change（APC），and average annual percentage change（AAPC） to analyze the temporal trends of annual all cancer incidence and mortality rates.Results: In 2018, the number of new cancer cases in Gansu was 13 592, with an incidence rate of 252.98/105, ASIRC and ASIRW were 189.79/105 and 205.89/105 respectively; there were 7,568 cancer deaths in the province, with a mortality rate of 140.86/105, ASMRC and ASMRW were 103.40/105 and 116.83/105 respectively. The ASIRC and ASMRC in urban areas were lower than those in rural areas. The incidence of cancer in males and females peaked in the 80-84 and 75-79 age groups, respectively, and the mortality rates of cancer in both males and females peaked in the 80-84 age groups. From 2010 to 2018, the ASIRC of cancer in the cancer registration areas of Gansu Province showed a downward trend (AAPC, -1.7%, 95%CI, -4.4%-10%), and the difference was not statistically significant (P>0.05). ASMRC showed a downward trend (AAPC, -3.9%, 95%CI,-10.0%-2.7%), the difference was not statistically significant (P>0.05).Conclusions: Digestive tract cancer, lung cancer and female breast cancer have high morbidity and mortality in Gansu Province, and are the main cancer types for the prevention and control of cancer in Gansu Province. According to the epidemic characteristics of cancer, multi-dimensional joint efforts should be made to promote the prevention of cancer populations in our province and reduce the disease burden of cancer in Gansu Province.