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RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS
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Background: Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a fatal contagious infectious
disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against
DVH.
Materials and Methods: Raw Rehmannia Radix Polysaccharide (RRRP), Lycii Fructus polysaccharides and
Astragalus Radix polysaccharides were experimented in vitro and in vivo. Mortality rate, livers change, liver lesion
scoring, peroxidative injury evaluation indexes in vitro and in vivo, and hepatic injury evaluation indexes of optimal
one were detected and observed in this experiment.
Results: RRRP could reduce mortality with the protection rate about 20.0% compared with that of the viral control
(VC) group, finding that RRRP was the most effective against DHAV. The average liver scoring of the VC, blank
control (BC), RRRP groups were 3.5, 0, 2.1. Significant difference (P
African Traditional Herbal Medicine Supporters Initiative (ATHMSI)
Title: RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS
Description:
Background: Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a fatal contagious infectious
disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against
DVH.
Materials and Methods: Raw Rehmannia Radix Polysaccharide (RRRP), Lycii Fructus polysaccharides and
Astragalus Radix polysaccharides were experimented in vitro and in vivo.
Mortality rate, livers change, liver lesion
scoring, peroxidative injury evaluation indexes in vitro and in vivo, and hepatic injury evaluation indexes of optimal
one were detected and observed in this experiment.
Results: RRRP could reduce mortality with the protection rate about 20.
0% compared with that of the viral control
(VC) group, finding that RRRP was the most effective against DHAV.
The average liver scoring of the VC, blank
control (BC), RRRP groups were 3.
5, 0, 2.
1.
Significant difference (P.
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