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Kinetic Mechanisms in Protein Folding
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AbstractOriginally published in: Protein Folding Handbook. Part I. Edited by Johannes Buchner and Thomas Kiefhaber. Copyright © 2005 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30784‐2The sections in this article areIntroductionAnalysis of Protein Folding Reactions using Simple Kinetic ModelsGeneral Treatment of Kinetic DataTwo‐state Protein FoldingComplex Folding KineticsHeterogeneity in the Unfolded StateFolding through IntermediatesRapid Pre‐equilibriaFolding through an On‐pathway High‐energy IntermediateA Case Study: the Mechanism of Lysozyme FoldingLysozyme Folding atpH5.2 and Low Salt ConcentrationsLysozyme Folding at pH 9.2 or at High Salt ConcentrationsNon‐exponential KineticsConclusions and OutlookProtocols–Analytical Solutions of Three‐state Protein Folding ModelsTriangular MechanismOn‐pathway IntermediateOff‐pathway MechanismFolding Through an On‐pathway High‐Energy IntermediateAcknowledgments
Title: Kinetic Mechanisms in Protein Folding
Description:
AbstractOriginally published in: Protein Folding Handbook.
Part I.
Edited by Johannes Buchner and Thomas Kiefhaber.
Copyright © 2005 Wiley‐VCH Verlag GmbH & Co.
KGaA Weinheim.
Print ISBN: 3‐527‐30784‐2The sections in this article areIntroductionAnalysis of Protein Folding Reactions using Simple Kinetic ModelsGeneral Treatment of Kinetic DataTwo‐state Protein FoldingComplex Folding KineticsHeterogeneity in the Unfolded StateFolding through IntermediatesRapid Pre‐equilibriaFolding through an On‐pathway High‐energy IntermediateA Case Study: the Mechanism of Lysozyme FoldingLysozyme Folding atpH5.
2 and Low Salt ConcentrationsLysozyme Folding at pH 9.
2 or at High Salt ConcentrationsNon‐exponential KineticsConclusions and OutlookProtocols–Analytical Solutions of Three‐state Protein Folding ModelsTriangular MechanismOn‐pathway IntermediateOff‐pathway MechanismFolding Through an On‐pathway High‐Energy IntermediateAcknowledgments.
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