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TOPICAL EPINEPHRINE VERSUS INFILTRATIVE EPINEPHRINE -WHAT IS SAFE FOR HEMOSTASIS IN ENDOSCOPIC SINUS SURGERY?
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Aim: The study intents to compare the safety & efcacy of topical application versus intranasal injection of epinephrine during endoscopic sinus
surgery(ESS) under general anaesthesia(GA) Materials and Methods: This is a tertiary hospital based ,1 year prospective study conducted in 200
patients randomly divided into 2 groups,with group I receiving topical application of 1:2000 epinephrine and group II receiving intranasal
inltration of 1:1,00,000 epinephrine,within age group of 10-60 years of both sexes who underwent ESS at GGH,Kurnool from January 2022 to
December 2022.Intraoperative hemostatic and hemodynamic parameters following topical application and intranasal injection of epinephrine
were analyzed Results: There were no signicant hemodynamic changes or electrocardiographic abnormalities following topical application of
1:2000 epinephrine.There was increase in heart rate,Systolic and Diastolic blood pressure and mean arterial pressure following intranasal injection
of epinephrine in study population(P<0.001).12% of study population developed electrocardiogram variation in form of sinus tachycardia
following local inltration with 1:1,00,000 epinephrine.Using a standardised scale -Fromme-Boezaart grading to assess hemostasis,no statistical
difference in the 2 groups was observed(P>0.05) Conclusion: Topical application of 1:2000 dilution of epinephrine gives similar hemostatic
effects compared to intranasal inltration of 1: 1,00,000 dilution of adrenaline during ESS,and is safe due to no signicant hemodynamic
abnormalities and thus we can avoid the systemic adverse events such as tachycardia,arrhythmia and mean arterial pressure changes due to
epinephrine inltration
Title: TOPICAL EPINEPHRINE VERSUS INFILTRATIVE EPINEPHRINE -WHAT IS SAFE FOR HEMOSTASIS IN ENDOSCOPIC SINUS SURGERY?
Description:
Aim: The study intents to compare the safety & efcacy of topical application versus intranasal injection of epinephrine during endoscopic sinus
surgery(ESS) under general anaesthesia(GA) Materials and Methods: This is a tertiary hospital based ,1 year prospective study conducted in 200
patients randomly divided into 2 groups,with group I receiving topical application of 1:2000 epinephrine and group II receiving intranasal
inltration of 1:1,00,000 epinephrine,within age group of 10-60 years of both sexes who underwent ESS at GGH,Kurnool from January 2022 to
December 2022.
Intraoperative hemostatic and hemodynamic parameters following topical application and intranasal injection of epinephrine
were analyzed Results: There were no signicant hemodynamic changes or electrocardiographic abnormalities following topical application of
1:2000 epinephrine.
There was increase in heart rate,Systolic and Diastolic blood pressure and mean arterial pressure following intranasal injection
of epinephrine in study population(P<0.
001).
12% of study population developed electrocardiogram variation in form of sinus tachycardia
following local inltration with 1:1,00,000 epinephrine.
Using a standardised scale -Fromme-Boezaart grading to assess hemostasis,no statistical
difference in the 2 groups was observed(P>0.
05) Conclusion: Topical application of 1:2000 dilution of epinephrine gives similar hemostatic
effects compared to intranasal inltration of 1: 1,00,000 dilution of adrenaline during ESS,and is safe due to no signicant hemodynamic
abnormalities and thus we can avoid the systemic adverse events such as tachycardia,arrhythmia and mean arterial pressure changes due to
epinephrine inltration.
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