Sepsis: The New Approach to The Successful Solving of The Problem

Background: The significant improvement of immediate and long-term functional results of treating of patients is the fundamental problem of modern medical science. A deep understanding of the pathogenesis is the key point in creating the management strategy for patients with various diseases. Information about the mechanisms of origin and development of purulent-inflammatory diseases and sepsis is essential for finding effective ways to prevent and treat them. The aim of the research is to use the method of fluorescence spectroscopy in creating pathogenetic diagnostic and treatment model for the prevention and treatment of purulent-inflammatory diseases and sepsis. Methods: Stage 1 consisted of an in vitro study, Stage 2 covered - 100 patients with surgical purulent-inflammatory diseases (including 15 patients with sepsis), Stage 3 engaged 180 women with postpartum purulent-inflammatory diseases (main group), 40 women with uncomplicated course of the postpartum period (control group), Stage 4 involved 20 patients with burn injury (main group), 35 people with burn injury (comparison group). In addition to standard treatments, patients also underwent serum studies using the method of fluorescence spectroscopy. Result(s): We have proposed the pathogenetic concept of diagnostic and treatment approach for purulent-inflammatory diseases and sepsis. As part of the method of fluorescence spectroscopy, thorough studies of the serum of patients with postpartum purulent-inflammatory diseases, of patients with a surgical profile, including sepsis, as well as burns trauma were conducted. A thorough analysis of the obtained results was provided. Conclusion(s): Based on our proposed pathogenetic concept, the possible mechanisms of sepsis and effective methods of diagnosis, monitoring and prognosis for its spread are discussed in details. It is proposed to use the pathogenetic component of the treatment of purulent-inflammatory diseases and sepsis on the basis of the pathogenetic model, which has been developed by us.