Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Evaluation of a Novel Osteoporotic Drug Delivery System In Vitro: Alendronate-Loaded Calcium Phosphate Cement
View through CrossRef
As a new drug delivery system, calcium phosphate cement was fabricated with different concentrations of alendronate (2, 5, 10 wt%), which is widely used to treat diseases related to bone loss. This study investigated the properties of the novel composite alendronate-loaded calcium phosphate cement in vitro, and found that the structure and chemical properties of the composites were not different from the calcium phosphate cement. However, the calcium phosphate cement set time was significantly faster compared with other groups (
P
<.01), and the strength of the calcium phosphate cement was significantly greater than the other groups (
P
<.01). The alendronate release rate from the composite increased with increase in drug concentration in the cement, and release was sustained over 21 days. The composite showed good biocompatibility in terms of the proliferation of rat mesenchymal stem cells. The alendronate-loaded calcium phosphate cement displayed satisfactory properties in vitro, which may be of benefit locally for osteoporotic bone in vivo.
Title: Evaluation of a Novel Osteoporotic Drug Delivery System In Vitro: Alendronate-Loaded Calcium Phosphate Cement
Description:
As a new drug delivery system, calcium phosphate cement was fabricated with different concentrations of alendronate (2, 5, 10 wt%), which is widely used to treat diseases related to bone loss.
This study investigated the properties of the novel composite alendronate-loaded calcium phosphate cement in vitro, and found that the structure and chemical properties of the composites were not different from the calcium phosphate cement.
However, the calcium phosphate cement set time was significantly faster compared with other groups (
P
<.
01), and the strength of the calcium phosphate cement was significantly greater than the other groups (
P
<.
01).
The alendronate release rate from the composite increased with increase in drug concentration in the cement, and release was sustained over 21 days.
The composite showed good biocompatibility in terms of the proliferation of rat mesenchymal stem cells.
The alendronate-loaded calcium phosphate cement displayed satisfactory properties in vitro, which may be of benefit locally for osteoporotic bone in vivo.
Related Results
Novel phosphate-based cements for clinical applications
Novel phosphate-based cements for clinical applications
This Thesis aims at the development of two novel families of inorganic phosphate cements with suitable characteristics for clinical applications in hard tissue regeneration or repl...
The cement-bone bond is weaker than cement-cement bond in cement-in-cement revision arthroplasty. A comparative biomechanical study
The cement-bone bond is weaker than cement-cement bond in cement-in-cement revision arthroplasty. A comparative biomechanical study
This study compares the strength of the native bone-cement bond and the old-new cement bond under cyclic loading, using third generation cementing technique, rasping and contaminat...
British Food Journal Volume 45 Issue 9 1943
British Food Journal Volume 45 Issue 9 1943
I now pass on to an aspect of calcium metabolism which is more topical, but probably more controversial. I refer to the incidence of calcium deficiency. By what means can we determ...
Cement Evaluation - A Risky Business
Cement Evaluation - A Risky Business
Abstract
Cement evaluation is commonly thought of as running a cement bond log (CBL) and attempting to interpret the results to determine if there is isolation in th...
COMPARISON OF ALENDRONATE, CALCITONIN AND CALCIUM TREATMENTS IN POSTMENOPAUSAL OSTEOPOROSIS
COMPARISON OF ALENDRONATE, CALCITONIN AND CALCIUM TREATMENTS IN POSTMENOPAUSAL OSTEOPOROSIS
SUMMARYThe present study was planned to assess the safety, tolerability and efficacy on bone mineral density (BMD), pain, quality of life and fracture risk of alendronate, calciton...
P0883HEALTHY FEMALES EXCRETE MORE PHOSPHATE THAN MALES IN RESPONSE TO AN ORAL CHALLENGE
P0883HEALTHY FEMALES EXCRETE MORE PHOSPHATE THAN MALES IN RESPONSE TO AN ORAL CHALLENGE
Abstract
Background and Aims
There are disparities in the diagnosis, treatment and prognosis for cardiovascular disease (CVD) be...
Risk factors for bone cement displacement after percutaneous vertebral augmentation for osteoporotic vertebral compression fractures
Risk factors for bone cement displacement after percutaneous vertebral augmentation for osteoporotic vertebral compression fractures
PurposeTo explore the risk factors of bone cement displacement after percutaneous vertebral augmentation (PVA) in patients with osteoporotic vertebral compression fracture (OVCF).M...
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
BACKGROUND
As of July 2020, a Web of Science search of “machine learning (ML)” nested within the search of “pharmacokinetics or pharmacodynamics” yielded over 100...