Association of nonalcoholic fatty liver disease with uric acid, BMI and dyslipidemia.

Abstract: Introduction: Nonalcoholic fatty liver disease (NAFLD) is gradually recognized as a main health challenge especially in the developed countries. NAFLD comprises of a series of liver damage that may vary from simple steatotic fluctuations to nonalcoholic steatohepatitis, fibrosis and progression to cirrhosis. Objectives: To assess the association of non-alcoholic fatty liver disease with BMI, lipid profile and serum uric acid. Methodology: This comparative study, after approval from Ethical review Board of the Institute, was carried out at Sharif Medical city hospital, a tertiary care hospital. The 200 patients of nonalcoholic fatty liver disease (NAFLD) were selected from the medical ward, considering inclusion and exclusion criteria. For control group, subjects were recruited from local population. The obtained data was statistically analyzed using SPSS version 23.0. The parameters compared between two groups includes lipid profile, serum uric acid, diastolic and systolic blood pressure, BMI and age. Results: Significant statistical differences were seen between the results of two groups. Mean serum uric acid found raised in study group when compared with controls. BMI along with diastolic and systolic blood pressures were seen to be elevated in NAFLD group. Dyslipidemia was also found to be present in NAFLD group. Conclusions: The study can be concluded that raised BMI, serum cholesterol and triglycerides and uric acid are correlated with progress of the non-alcoholic fatty liver disease. These findings can be used by the physicians for early detection and prevention of the progression of NAFLD.   Keywords: uric acid, Non-alcoholic fatty liver disease, body mass index.