Association of plasma Omentin-1 and gestational diabetes mellitus in local population of Pakistan.

Objective: To determine plasma omentin-1 levels in pregnant females suffering from gestational diabetes mellitus. Study Design: Case Control study. Setting: Outpatient Department of Obstetrics and Gynecology, Tertiary Care Hospital of Karachi, Pakistan. Period: June 2021 to December 2021. Material & Methods: Ninety-nine gestational diabetic and ninety-six healthy pregnant women were included in this study. A diagnostic criterion for gestational diabetes was oral glucose tolerance test between 24th to 28th weeks of pregnancy. ELISA was performed at KIBGE lab for estimation of plasma omentin-1 levels. Data was analyzed by SPSS software version 22. Results: Mean age of the patients was 30.8±6.4 years. GDM patients had increased BMI (36.0± 6.6vs 32.3 ±4.7; p=0.001), FBG (110 ±14 vs 77± 9; p=0.001), however, plasma omentin-1levels (4.90±9.01vs 9.56±12.11; p=0.001) were found reduced in GDM as compared to nGDM females. Statistically significant negative correlation was found between plasma omentin-1 and body mass index (BMI) (p=0.02). Simple and multi variable regression analysis revealed the statistically significant association of plasma omentin-1 with GDM. Conclusion: Our study has concluded that reduced plasma omentin-1 levels may play a significant role in the development of GDM during pregnancy, so it might be a new possible biomarker for early GDM diagnosis.