Cerebral venous sinus thrombosis with head trauma and myeloproliferative neoplasm-unclassifiable: A case report

Rationale: Cerebral venous and sinus thrombosis (CVST) is a rare and special type of cerebrovascular disease characterized by complex etiology, diverse forms of onset, nonspecific clinical manifestations, and difficult diagnosis. Myeloproliferative neoplasm–unclassifiable (MPN-U) refers to clinical manifestations, laboratory findings, and morphological features that are consistent with the diagnosis of myeloproliferative neoplasms, but do not meet further specific classification criteria, or have overlapping features of 2 or more myeloproliferative neoplasms. Here, we report a case of CVST with MPN-U and a history of head trauma. This case report emphasizes the need to recognize such manifestations to avoid misdiagnosis and ensure timely treatment. Patient concerns: This case report presents a cerebral venous sinus thrombosis with head trauma and an unclassifiable myeloproliferative neoplasm male patient who experienced visual impairment with hearing loss, cerebration trauma. Diagnoses: CVST with MPN-U. Interventions: The anticoagulant treatment with low molecular weight heparin were administered in the hospital, then rivaroxaban was given after discharge. Outcomes: His blurred vision improved, and the sense of tightness in the parietal and occidental skin relieved at discharge. He took rivaroxaban 10 mg orally once a day after discharge. At 1-month follow-up, the blurred vision of this patient had significantly improved. Lessons: It is unique that CVST with blurred vision as the main clinical manifestation and 2 possible causes, including head trauma and MPN-U. For patients with CVST, in addition to anticoagulant therapy, it is also necessary to identify the etiologies.