TO DETERMINE THE EXPRESSION OF E-CADHERIN IN DIFFERENT HISTOLOGICAL SUBTYPES OF AMELOBLASTOMA FOR GAUGING AND PREDICTING THE AGGRESSIVENESS AND BEHAVIOR OF THIS TUMOR IN OUR POPULATION

Objective: The current study is designed to determine the expression of immunohistochemical markers E-Cadherin in different histological subtypes of ameloblastoma for gauging and predicting the aggressiveness and behavior of this tumor in our population. Materials and Methods: A total of 60 cases of ameloblastoma were collected for this study from June2016 to June 2017, in AFIP Rawalpindi. The tumor was sub-classified histologically on the basis of WHO classification. Final results were analyzed. Mean and standard deviation were calculated for quantitative variables. Frequency and percentages were calculated for qualitative variables. Chi square test was applied to find the association of E-Cadherin with histological variants of ameloblastoma. P –VALUE <0.05 was considered significant. Results: All samples showed positive E-Cadherin expression with moderate to strong positivity. Highest positivity was observed at the level of stellate reticulum like cells, as they are closer to invasive font. Follicular type showed maximum immunoexpression (73.6%) significantly different from 25% of acanthomatous type. P value for E-Cadherin was calculated to be 0.156. Conclusion: E-Cadherin showed positive results in all histological subtypes of ameloblastoma with maximum intensity in follicular type and minimum in acanthomatous type.