Synthesis of magneto-plasmonic hybrid material for cancer hyperthermia

Magnetic nanoparticle CoFe2O4-based hyperthermia is a promising non-invasive approach for cancer therapy. However, CoFe2O4 nanoparticles (NPs) have a low heat transfer efficiency, which limits their practical clinical applications. Hence, it is necessary to investigate the higher-performance magnetic NPs-based hybrid nanostructures to enhance their magnetic hyperthermia efficiency. This work presents a facile in situ approach for synthesizing cobalt ferrite (CoFe2O4) silver (Ag) hybrid NPs as optical-magnetic hyperthermia heat mediators. The prepared cobalt ferrite silver hybrid NPs exhibit a higher heat generation than that of individual Ag or CoFe2O4 NPs under simultaneous exposure to an alternating current magnetic field and laser source. The obtained results confirm that the hybridization of CoFe2O4 and Ag NPs could significantly enhance the hyperthermia efficiency of the prepared NPs. Therefore, the CoFe2O4-Ag hybrid NPs are considered as potential candidates for a high-performance hyperthermia mediator based on a simple and effective synthesis approach.