Study of the Chemical Components and Bioactivities of Rhodomyrtus Tomentosa Extracts

Rhodomyrtus tomentosa is a flowering plant belonging to the family Myrtaceae. In this study, sample was leaves of Rhodomyrtus tomentosa. Three compounds were isolated from n-hexan extract (RTH), their structures were identified by proton and carbon 13 NMR spectral dât and compared with spectral data in the literature: rhodomyrtosone, combretol and loliolide. Determination of total flavonoids (TF) and phenolic (TP) compounds were shown that ethylacetate extract has the higher value for both TF and TP (25.32 mg BHT/g; 60.01 mg GAE/g) compared n-hexan extract.   Keywords Rhodomyrtus tomentosa, rhodomyrtosone, combretol, loliolide, total flavonoids content, total phenolic content References [1] Csurhes S., Hankamer C. Ceylon Hill Cherry (DownyRose Myrtle): Rhodomyrtus tomentosa. Brisbane, Queensland, Australia: Biosecurity Queensland, 2016 . [2] Do T. L. Medicine Plants and Remedies of Vietnam. Hanoi: Thoi Dai publisher, 434, 2004.[3] Arya V. A review on anti tuberculosis plants. Int. J. PharmaTech. Res., vol 3(2), 872-880, 2011.[4] Ong H, Nordiana M. Malay ethno‑medico botany in Machang, Kelantan, Malaysia. Fitoterapia, vol. 70(5), 502‑13, 1999.[5] Wei F. Manufacture of Oral Liquid Containing Traditional Chinese Medicine Extract for Treating Gynecopathy (Guangxi Huahong Pharmaceutical Co., Ltd., People’s Republic of China; Shanghai Fosun Pharmaceutical (Group) Co., Ltd.), Faming Zhuanli Shenqing Gongkai Shuomingshu. People’s Republic of China Patent CN1846715, 2006. [6] Chuakul W. Medicinal plants in the Khok Pho district, Pattani province (Thailand). Thai J. Phytopharm, vol. 12, 23‑45, 2005. [7] Geetha K. M., Sridhar, C., Murugan V. Antioxidant and Gastroprotective activities of Rhodomyrtus tomentosa (Ait.) Hassk. International Journal of PharmTech Research, vol 2(1), 283-291, 2010.[8] Jeong D., Yang W. S., Yang Y., Nam G., Kim J. H., Yoon D. H., Noh H. J., Lee S., Kim T. W., Sung G., Cho, J. Y. In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract. Journal of Ethnopharmacology, vol. 146, 205-213, 2013. [9] Lavanya G., Voravuthikunchai S. P., Towatana N. H. Acetone extract from Rhodomyrtus tomentosa: A potenr natural antioxidant. Evidence Based Complementary and Alternative Medicine, vol. 10, 1155-5, 2012.[10] Lai T. N. H., André C., Rogez H., Mignolet E., Nguyen T. B. T., Larondelle, Y. Nutritional composition and antioxidant properties of the simfruit (Rhodomyrtus tomentosa). Journal of Food Chemistry, vol. 168, 410-426, 2014.[11] Lai, T. N. H., Herent, M., Quentin-Leclerq J., Nguyen T.B. T., Rogez H., Larondelle Y., André C. M. Piceatannol, a potent bioactive stilbene, as major phenolic component in Rhodomyrtus tomentosa. Journal of Food Chemistry, vol. 138, 1421-1430, 2012.[12] Cui C., Zhang S., You L., Ren J., Luo W., Chen W., Zhao, M. Antioxidant capacity of anthocyanins from Rhodomyrtus tomentosa (Ait.) and identification of the major anthocyanins. Journal of Food Chemistry, vol. 139, 1-8, 2013.[13] Lim T. Rhodomyrtus tomentosa. Edible medicinal and non medicinal plants. New York: Springer, 732‑7, 2012.[14] Wu X., Beecher G.R., Holden J.M., Haytowitz D.B., Gebhardt S.E., Prior R.L. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem, vol. 52(12), 4026‑37, 2004.[15] Limsuwan S., Hesseling‑Meinders A., Voravuthikunchai S.P., Van Dijl J.M., Kayser O. Potential antibiotic and anti‑infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics. Phytomedicine, vol18(11), 934‑40, 2011.[16] Marinova D., Ribarova F., Altanassova. Total phenolics and total flavonoids in Bulgarian fruits and vegetables. Journal of The University of Chemical Technology and Metallurgy, vol 40, 255-260, 2005.[17] Dachriyanus, Salni, Sargent M.V., Skelton B. W., Soediro I., Sutisna M., White A. H., Yulinah E. Rhodomyrtone, an antibiotic from Rhodomyrtus tomentosa. Aust. J. Chem, Vol. 55, 229-232, 2002.[18] Dachriyanus, Fahmi R., Sargent M.V., Skelton B. W., White A. H., Yulinah E. 5-Hydroxy-3,3’,4’,5’,7-pentamethoxyflavone (combretol). Acta Cryst.,, Vol. E60, 86-88, 2004.[19] Hoges R. and Porte A.L. The structure of loliolide: A terpene from Lolium perenne. Tetrahedron, Vol. 20, 1463-1467, 1964.[20] Kimura J., Maki N. New loliolide derivatives from the brown alga Undaria pinnatifida. J. Nat. Prod., Vol 65, 57-58, 2002. [21] https://www.psychologytoday.com/us/articles/200307/flavonoids-antioxidants-help-the-mind.[22] https://www.nutraingredients.com/Article/2008/10/10/Flavonoids-heart-health-benefits-in-the-blood-vessels-Study