Patterns of Hba1c Levels in Normoglycemic Offspring of T2 Diabetes Mellitus Patients

Background: The risk of developing diabetes mellitus for an individual with a positive family history of the disease is two- to fourfold higher in an offspring of a diabetic compared with offspring of non-diabetic shown by serum glycated hemoglobin (HbA1c) levels. There is paucity of data on pre-diabetes in our environment. Objectives: This study was designed to determine the baseline HbA1c levels of normoglycemic offspring of type 2 diabetes mellitus (T2DM) patients in Ijebu-ode, Nigeria. Methods: This is a cross-sectional study of offspring of T2DM patients (ODP) and those of offspring of non-diabetic parents (ONDP). Diabetic offspring were exempted from the study. FBS was determined using enzymatic hexokinase method to determine glucose concentrations and exclude diabetes. Serum HbA1c was measured using standard method. Height and weight were measured using standard methods. Body mass index (BMI) was calculated. Results: There were 100 ODP and 100 ONDP aged 16 to 40 years. The most populated aged group was 21 to25 years which is 44% (n=88). 6% (n=12) of the study group were obese. 19% were overweight (n=38). The mean weight of ODP was significantly higher than that of ONDP (P=0.020). Also, the mean HBA1c of ODP was significantly higher than that of ONDP (P<0.001). Conclusion: The serum HbA1c level was significantly higher among ODP than ONDP. The mean weight was significantly higher in ODP than ONDP.