Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
DESMOSOMES IN ORAL DISEASES – A REVIEW
View through CrossRef
Desmosomes are the adhesion proteins that function both as an adhesive complex and as a cell surface attachment site for keratin intermediate filaments of the cytoskeleton. Desmosomes are more widely distributed along the lateral membranes. Desmosomes contain two types of transmembrane proteins desmogleins and desmocollins which belong to cadherin family. These desmosomal cadherins are linked to the keratin cytoskeleton via several cytoplasmic proteins such as desmoplakin and plakoglobin. Desmosomes play a critical role in the maintenance of normal tissue architecture. They are frequently mutated and desmosomal adhesion is compromised by antibodies in autoimmune diseases and result in blistering disorders in epithelium. Inherited mutations in genes in desmosomal constituents can also affect the skin and the heart. Desmosomes may have a tumour suppressor function and desmosomal cadherins have the capacity to suppress the invasiveness of cells in culture.
Title: DESMOSOMES IN ORAL DISEASES – A REVIEW
Description:
Desmosomes are the adhesion proteins that function both as an adhesive complex and as a cell surface attachment site for keratin intermediate filaments of the cytoskeleton.
Desmosomes are more widely distributed along the lateral membranes.
Desmosomes contain two types of transmembrane proteins desmogleins and desmocollins which belong to cadherin family.
These desmosomal cadherins are linked to the keratin cytoskeleton via several cytoplasmic proteins such as desmoplakin and plakoglobin.
Desmosomes play a critical role in the maintenance of normal tissue architecture.
They are frequently mutated and desmosomal adhesion is compromised by antibodies in autoimmune diseases and result in blistering disorders in epithelium.
Inherited mutations in genes in desmosomal constituents can also affect the skin and the heart.
Desmosomes may have a tumour suppressor function and desmosomal cadherins have the capacity to suppress the invasiveness of cells in culture.
Related Results
Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure
Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure
The resistance of tissues to physical stress is dependent upon strong cell-cell adhesion in which desmosomes play a crucial role. We propose that desmosomes fulfil this function by...
Oral Manifestation of Sexual Transmitted Diseases
Oral Manifestation of Sexual Transmitted Diseases
Abstract: Sexually transmitted diseases (STDs) are transmitted through sexual contact, and can manifest in the oral cavity. This study aimed to determine the oral manifestations of...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical activi...
4.N. Workshop: Maternal Oral Health Models and Initiatives in Global and Public Health Perspectives
4.N. Workshop: Maternal Oral Health Models and Initiatives in Global and Public Health Perspectives
Abstract
Achieving and maintaining good oral health is essential for both the oral and overall health of expecting mothers and...
The Role of Oral Health in the Prevention of Systemic Diseases
The Role of Oral Health in the Prevention of Systemic Diseases
Oral health plays a crucial role in maintaining overall well-being , as it is closely linked to the prevention of systemic diseases. This abstract aims to provide a comprehensive o...
DENTAL STATUS OF PRESCHOOL CHILDREN WITH MOUTH BREATHING
DENTAL STATUS OF PRESCHOOL CHILDREN WITH MOUTH BREATHING
There is an increase in the number of children who have complicated nose breathing and its oral type. Preschool children are of particular concern according to clinicians. These ci...
Abstract 178: Desmosome mutations in melanoma promote cellular proliferation and disease progression
Abstract 178: Desmosome mutations in melanoma promote cellular proliferation and disease progression
Abstract
Desmosomes are transmembrane protein complexes that contribute to cell-cell adhesion in the epithelia and other tissues under mechanical stress. Aberrant de...
P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly
P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly
Abstract
Desmosomes are essential adhesive junctions that mediate the integrity of tension prone tissue like the heart and skin. The classical cadherin, P-cadherin ...