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Renal metastasis of ovarian granulosa cell tumor

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IntroductionWe would like to present a rare case of metastatic renal tumor.Case presentationA 60‐year‐old woman presented to our department with a left renal tumor. She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago. She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary.The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy. Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation. Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor.ConclusionTo our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.
Title: Renal metastasis of ovarian granulosa cell tumor
Description:
IntroductionWe would like to present a rare case of metastatic renal tumor.
Case presentationA 60‐year‐old woman presented to our department with a left renal tumor.
She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago.
She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary.
The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy.
Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation.
Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor.
ConclusionTo our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.

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