Evaluation of gastroprotective effects of Senegalia chundra bark extract on gastric ulcers in wistar albino rats

Peptic ulcer disease (PUD) affects around 10% of the global population and results from an imbalance between the stomach’s protective mechanisms and aggressive factors like hydrochloric acid and pepsin. This study examines the potential of the ethanolic extract of Senegalia chundra bark in protecting against gastric ulcers in Wistar albino rats, induced by indomethacin and pylorus ligation. The research highlights key mechanisms contributing to ulcer formation, such as the involvement of Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drugs (NSAIDs). In vitro antioxidant tests, including the DPPH method, showed that the Senegalia chundra extract had significant free radical scavenging activity, similar to that of ascorbic acid. Histological analysis further supported the protective effects of the extract, showing that it could reduce ulcer formation. These findings suggest that Senegalia chundra bark extract may hold promise as a natural therapeutic agent for managing peptic ulcers. The study emphasizes the role of bioactive compounds such as flavonoids and tannins in the plant’s medicinal properties, which may contribute to its effectiveness. The research adds to the growing body of evidence advocating for the integration of plant-based treatments in modern medicine, particularly for gastrointestinal conditions like PUD. This supports the ongoing exploration of traditional herbal remedies as alternative or complementary options for treating gastric ulcers and related disorders. The potential of Senegalia chundra as a safe and effective natural remedy underscores the need for further studies to confirm its therapeutic value and mechanisms of action.