Comparison of sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning

Abstract Endocrine disrupting chemicals or xenoestrogens are natural or synthetic compounds that have the ability to disrupt the endocrine system by mimicking or blocking endogenous hormones. Therefore, the aim of the present study was to compare sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning. For this purpose, 30 mice were purchased and divided into 5 groups of 6 for testing. The rats in the first group were negative control , second group received propylene glycol as vehicle control and in the following groups received different doses of bisphenol A (from 50 mg/kg/daily to 600 mg/kg/daily) . Then, the sperms were sampled and the quality indicators of the sperms such as percentage of motility, viability, etc. were evaluated. Finally, using statistical methods, the results obtained in the present study were statistically analyzed. The average indices of concentration (p=0.001), motility and amount of progressive sperm (p=0.003), amount of motile sperm (p=0.001), live sperm (p=0.0001) and sperm with normal morphology (p=0.003) in the receiving groups Bisphenol A was significantly reduced. The study shows that , the chemical bisphenol A has a very destructive effect on sperm and effectively causes infertility.