Frailty in older adults admitted to hospital: outcomes from the Western Sydney Clinical Frailty Registry.

Abstract Objectives To report the baseline profile, clinical management, all-cause rehospitalisation, and mortality at 12 months of adults enrolled into the Western Sydney Clinical Frailty Registry. Design: Prospective observational cohort study Setting and Participants: 592 adults admitted to an acute geriatric medicine service in NSW, Australia, were included in this study. Methods The Western Sydney Clinical Frailty Registry is a study of adults admitted to acute geriatric wards in a 570-bed two-site district general hospital in Western Sydney NSW, Australia. Recruitment began in April 2020 and is ongoing. Each participant is recruited while an inpatient and followed up for 12 months including baseline visits and three-, six- and 12-month follow-ups via telephone interviews. The primary outcome of this study was rehospitalisation and/or mortality at 12 months. Results Median age 82 years; half the cohort were classified as mild-moderately frail and 21% were classified as severely frail. A total of 134 participants died (22.6%) within the 12-month follow-up period. Increased cumulative incidence of first rehospitalisation and/or death during the first 12 months post-discharge was significantly associated with higher modified Charlson comorbidity (p < 0.001) and Clinical Frailty Scale (CFS) scores (p < 0.001). Compared to the ‘non-frail’ group (CFS 1–4), those who were severely frail (CFS 7–9) had an 85% increased risk of rehospitalisation and/or death, and those who were mild-moderately frail (CFS 5–6) had a 52% increased risk after adjusting for effects of the other variables. Conclusions Frailty is very common in older adults admitted to acute geriatric services. Assessing frailty using the CFS is feasible and is independently predictive of rehospitalisation and mortality. Our findings suggest that integrating frailty assessment into clinical practice goes beyond simple risk stratification, offering valuable insights for tailored clinical management strategies.