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Sesamin Ameliorates Insulin Resistance Induced by High Glucose/High Insulin in Hepatic L02 Cells
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In this study, the antioxidant effect of sesamin on insulin resistance in hepatic L02 cells induced by high glucose/high insulin was investigated. Results showed that treatment with sesamin (200, 100 μg/ml) increased the cell viability, activity of superoxide dismutase and glutathione peroxidase, and the content of reduced glutathione of L02 hepatocyte model of insulin-resistance. Moreover, treatment with sesamin decreased the content of malondialdehyde, production of nitric oxide, and the activity of nitric oxide synthase, inducible nitric oxide synthase, and gene expression levels of c-Jun NH2-terminal kinase significantly. The destructive change of hepatic L02 cells was ameliorated when treated with sesamin under microscopic observation. In conclusion, sesamin has anti-oxidative effect on the L02 hepatocyte model of insulin resistance induced by high glucose/high insulin.
New Century Health Publishers LLC
Title: Sesamin Ameliorates Insulin Resistance Induced by High Glucose/High Insulin in Hepatic L02 Cells
Description:
In this study, the antioxidant effect of sesamin on insulin resistance in hepatic L02 cells induced by high glucose/high insulin was investigated.
Results showed that treatment with sesamin (200, 100 μg/ml) increased the cell viability, activity of superoxide dismutase and glutathione peroxidase, and the content of reduced glutathione of L02 hepatocyte model of insulin-resistance.
Moreover, treatment with sesamin decreased the content of malondialdehyde, production of nitric oxide, and the activity of nitric oxide synthase, inducible nitric oxide synthase, and gene expression levels of c-Jun NH2-terminal kinase significantly.
The destructive change of hepatic L02 cells was ameliorated when treated with sesamin under microscopic observation.
In conclusion, sesamin has anti-oxidative effect on the L02 hepatocyte model of insulin resistance induced by high glucose/high insulin.
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