Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Stereochemistry of α‐aminoisobutyric acid peptides in solution: Conformations of decapeptides with a central triplet of contiguous L‐amino acids
View through CrossRef
AbstractThe decapeptides Boc‐Aib‐L‐Val‐Aib‐Aib‐(L‐Val)3‐Aib‐L‐Val‐Aib‐OMe and Boc‐Aib‐L‐Leu‐Aib‐Aib‐(L‐Leu)3‐Aib‐L‐Leu‐Aib‐OMe have been studied in CDCl3 and (CD3)2SO solutions by 270‐MHz1 H‐nmr. In CDCl3, the presence of eight intramolecularly hydrogen‐bonded NH groups has been established, consistent with a 310‐helical conformation, for both decapeptides. In (CD3)2SO, only seven solvent‐shielded NH groups are observed, supporting either an α‐helical conformation or a partially unfolded 310‐helix. Ir studies provided supporting evidence for intramolecularly hydrogen‐bonded structures in CHCl3, while CD studies suggest helical conformation in both decapeptides in various solvents. CD studies also support helical folding in the C‐terminal hexapeptides. The central triplet of L‐amino acids appears to destabilize 310‐helical conformations in polar solvents like (CD3)2SO.
Title: Stereochemistry of α‐aminoisobutyric acid peptides in solution: Conformations of decapeptides with a central triplet of contiguous L‐amino acids
Description:
AbstractThe decapeptides Boc‐Aib‐L‐Val‐Aib‐Aib‐(L‐Val)3‐Aib‐L‐Val‐Aib‐OMe and Boc‐Aib‐L‐Leu‐Aib‐Aib‐(L‐Leu)3‐Aib‐L‐Leu‐Aib‐OMe have been studied in CDCl3 and (CD3)2SO solutions by 270‐MHz1 H‐nmr.
In CDCl3, the presence of eight intramolecularly hydrogen‐bonded NH groups has been established, consistent with a 310‐helical conformation, for both decapeptides.
In (CD3)2SO, only seven solvent‐shielded NH groups are observed, supporting either an α‐helical conformation or a partially unfolded 310‐helix.
Ir studies provided supporting evidence for intramolecularly hydrogen‐bonded structures in CHCl3, while CD studies suggest helical conformation in both decapeptides in various solvents.
CD studies also support helical folding in the C‐terminal hexapeptides.
The central triplet of L‐amino acids appears to destabilize 310‐helical conformations in polar solvents like (CD3)2SO.
Related Results
SYNTHESIS OF AMINO ACIDS FROM SUBSTITUTED CYANOACETIC ESTERS
SYNTHESIS OF AMINO ACIDS FROM SUBSTITUTED CYANOACETIC ESTERS
Nine α-amino acids, namely, dl-α-aminoundecylic acid, dl-α-aminostearic acid, dl-α-amino-β-methylcaproic acid, dl-α-amino-β-ethylvaleric acid, dl-α-amino-β-methylenanthic acid, dl-...
Biosynthetic Strategies for Macrocyclic Peptides
Biosynthetic Strategies for Macrocyclic Peptides
Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for imp...
Molecular Dynamics Studies of Intrinsically Disordered Peptides and Proteins
Molecular Dynamics Studies of Intrinsically Disordered Peptides and Proteins
A tremendous amount of evidence has accumulated in regards to the importance of intrinsically disordered proteins (IDPs) in the functioning of the cell and their role in human dise...
Microwave Assisted Aza-michael Additions Towards β-amino Acids
Microwave Assisted Aza-michael Additions Towards β-amino Acids
Background:
β-amino acids are non-natural amino acids, where the amino group is
attached to the β-carbon instead of the α-carbon. Peptides containing β-amino acids present with
par...
Orbitrap and GC-Orbitrap for in situ analyses: clues from laboratory experiments
Orbitrap and GC-Orbitrap for in situ analyses: clues from laboratory experiments
<p>Introduction</p>
<p>The organic molecular diversity present in extraterrestrial bodies such as asteroids and comets is of great interes...
ANALISIS PROTEIN DAN ASAM AMINO NATTO, MAKANAN FERMENTASI KEDELAI KUNING OLEH BASILLUS SUBTILLIS NATTO
ANALISIS PROTEIN DAN ASAM AMINO NATTO, MAKANAN FERMENTASI KEDELAI KUNING OLEH BASILLUS SUBTILLIS NATTO
This Research aims to analyze crude protein and amino acid profile of natto from yellow soybeans from Vedca Cianjur. Protein analysis was performed using the Semi-micro Kjeldahl me...
Fast Transfer of Triplet to Doublet Excitons from Organometallic Host to Organic Radical Semiconductors
Fast Transfer of Triplet to Doublet Excitons from Organometallic Host to Organic Radical Semiconductors
AbstractSpin triplet exciton formation sets limits on technologies using organic semiconductors that are confined to singlet‐triplet photophysics. In contrast, excitations in the s...
Hypervelocity impact on amino acids embedded in water ice
Hypervelocity impact on amino acids embedded in water ice
Impacts are prevalent in the solar system and have played a profound role in the evolution of the solar system bodies. The delivery of prebiotic compounds through impact events is ...