A Rare Case of Plasma Cell Granuloma of Buccal Mucosa

Plasma cell granuloma, also known as inflammatory pseudotumor, is one of the rare nonneoplastic lesions seen predominantly in the oral cavity or head and neck region. Its etiology, incidence, and biological behavior remain unclear. We are reporting a case of plasma cell granuloma in a 42-year-old male presenting with a complaint of reddish-white swelling near the left lower teeth region since the last 3 years, treated by excisional biopsy. A provisional diagnosis of plasma cell granuloma was given. The plasma cell granuloma is a rare non-neoplastic lesion that was originally documented by Bahadori and Liebow in 1973.[1] It can occur anywhere in the body, in any organ or soft tissue, and is commonly seen in the lungs. Other sites of involvement are the brain, kidney, stomach, and heart. Within the head and neck region, this condition has been observed in various locations, including the oral mucosa, temporal bone, tonsil, submandibular region, paranasal sinuses, tongue, and gingiva.[2-6] Plasma cell granuloma is known by several names, like inflammatory myofibroblastic tumor, inflammatory pseudotumor, and inflammatory myofibrohistiocytic proliferation. It is formed by aggregates of mature plasma cells along with fibroblasts and histiocyte-type mesenchymal cells arranged in a granulomatous pattern.