Echinococcus granulosus İnfeksiyonu Tanısında Moleküler Uygulamalar ve Yeni Yaklaşımlar

Cystic echinococcosis (CE) is a chronic zoonotic disease which is distributed all over the world, causes a large disease burden, and characterized by prolonged growth of hydatid cysts in intermediate hosts. Echinococcus granulosus which is a CE agent and causes hydatid cysts in mostly in liver (65-70%) and lungs (20-25%) but also other organs (kidney 2%, spleen 2% and brain less than 2%, etc.). The diagnosis of CE is based on clinical fin-dings, imaging techniques, serological and molecular technics. Identification of Echinococcus DNA in patient se-rum may be an applicable non-invasive method in the diagnosis. Up to now, different genotypes of E. granulo-sus have been identified by using molecular techniques from humans and other intermediate hosts. But now, the molecular approaches are not restricted to DNA levels but also to RNA levels. Especially new developments in genomics, proteomics, microarray, and next generation sequencing analysis will be useful for the identifica-tion of additional targets for diagnosis, vaccination, and chemotherapy Using high throughput analysis met-hodologies can help to underly the mechanism of interaction between E. granulosus and its hosts. So, obtained new informations will be used to develop new therapeutic and diagnostic targets of E. granulosus infection