Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma

Abstract Purpose: The aim of this study was to investigate the relationship between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma tissues and its poor prognosis. RRBP1 is a nascent transporter on the rough endoplasmic reticulum. Its function is to regulate the transport and secretion of proteins in cells, and to relieve endoplasmic reticulum (ER) stress, thereby promoting tumor cell proliferation.Methods: The expression levels of RRBP1 in 96 cervical squamous cell carcinoma tissues were detected by immunohistochemistry. Western blot and qRT-PCR were used to compare the expression levels of RRBP1 in cervical squamous cell carcinoma tissues and normal cervical tissues. Then the chi-square test was used to analyze the results of immunohistochemistry. Finally, the Kaplan-Meier method was used to analyze the results by log-rank test and Cox regression (proportional risk model).Result: The overexpression of RRBP1 in cervical squamous cell carcinoma tissues was related to FIGO stage (P=0.030), tissue differentiation (P=0.047), lymph node metastasis (P=0.031), and was not related to the patient age (P=0.667). Univariate survival analysis showed that the prognosis was associated to the expression level of RRBP1 (P=0.045) and lymph node metastasis (P=0.001). Analysis of multi-factor survival cox model proved that RRBP1 was an independent prognostic factor. Conclusion: RRBP1 was overexpressed in cervical squamous cell carcinoma tissues, indicating that RRBP1 may be a new tumor marker for early diagnosis, treatment and prognosis of cervical squamous cell carcinoma, and it will provide help for individualized treatment and prognosis of cervical squamous cell carcinoma in the future.