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A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus
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Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.
Title: A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus
Description:
Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus.
The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy.
Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains.
Each MAb showed a distinct pattern of reactivity with HCV strains.
It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.
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