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Lambert-Eaton Myasthenia Syndrome
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Lambert-Eaton myasthenia syndrome (LEMS) is an autoimmune-mediated disorder of the neuromuscular junction, which involves autoantibodies to voltage-gated calcium channels on the presynaptic membrane. In this chapter, we discuss the characteristic clinical features of LEMS, its electrophysiological distinction from MG, as well as its paraneoplastic presentation. We also review the immunotherapeutic management options in cases with severe weakness and those refractory to tumor removal.
Title: Lambert-Eaton Myasthenia Syndrome
Description:
Lambert-Eaton myasthenia syndrome (LEMS) is an autoimmune-mediated disorder of the neuromuscular junction, which involves autoantibodies to voltage-gated calcium channels on the presynaptic membrane.
In this chapter, we discuss the characteristic clinical features of LEMS, its electrophysiological distinction from MG, as well as its paraneoplastic presentation.
We also review the immunotherapeutic management options in cases with severe weakness and those refractory to tumor removal.
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