Histopathological and Physiological Study of Nerium oleander and Lead on the Liver in the Male Albino Mice.

The current study prepareded to evaluate histopathological and some physiological parameters changes after treated with Nerium oleander L and lead. Thus study concentrated on some tissue structures in the liver after treated with the aqueous extract of Nerium oleander and lead solution. Its caused intense flaws in tissue structures of liver of treated albino mice. After the expiration of the experimental time, the blood specimens collecting to evaluate the value of Aspartate Transaminase (AST), Alanine Transaminase (ALT), urea (BUN) and creatinine (CR-S) in blood of treatmented animals, then animals sacrificed for histopatolological study The results of present study noted remarkable tissue changes in liver parenchyma, these changes included acute cellular destruction after treated with Nerium oleander and acute blood hemorrhage. The effects of lead showed clear space between hepatocyte of liver tissue, no prominent hepatic cords, most hepatocyte didn’t have normal nuclei. The Physiological alterations observed significantaly increased in the enzymes value (Aspartate Transaminase, Alanine Transaminase, (BUN) and (CR-S) ) when exposure to Oleander and lead compared with control group.