Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
View through CrossRef
Asthma is characterized by mucus abnormalities. Airway epithelial metaplasia results in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired culminating in mucus plugging and airway obstruction, a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma and recent work sheds light on their contribution to asthma pathogenesis. Herein we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.
Title: Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
Description:
Asthma is characterized by mucus abnormalities.
Airway epithelial metaplasia results in changes in stored and secreted mucin and the production of a pathologic mucus gel.
Mucus transport is impaired culminating in mucus plugging and airway obstruction, a major cause of morbidity in asthma.
The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus.
MUC5AC and MUC5B gene expression is altered in asthma and recent work sheds light on their contribution to asthma pathogenesis.
Herein we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.
Related Results
CDH26 amplifies airway epithelial IL-4 receptor α signaling in asthma
CDH26 amplifies airway epithelial IL-4 receptor α signaling in asthma
ABSTRACTBackgroundActivation of interleukin (IL)-4 receptor (R) signaling in airway epithelial cells leads to airway hyperresponsiveness and mucus overproduction in asthma. Cadheri...
ASTHMA AND RESPIRATORY SYMPTOMS RELATED TO THE ENVIRONMENT
ASTHMA AND RESPIRATORY SYMPTOMS RELATED TO THE ENVIRONMENT
Asthma, a ubiquitous chronic respiratory ailment, stands as a formidable global health concern, affecting millions of individuals across the world. This widespread condition, marke...
Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis
Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis
Cystic fibrosis (CF) airway disease is characterized by excessive and accumulative mucus in the airways. Mucociliary clearance becomes defective as mucus secretions become hypercon...
The Impact of Adverse Childhood Experiences on Asthma Severity in US Adults
The Impact of Adverse Childhood Experiences on Asthma Severity in US Adults
Background/objectives: The association between adverse childhood experiences (ACEs) and asthma severity among United States (US) adults with asthma has not been well documented. In...
Cometary Physics Laboratory: spectrophotometric experiments
Cometary Physics Laboratory: spectrophotometric experiments
<p><strong><span dir="ltr" role="presentation">1. Introduction</span></strong&...
Prevalence of Comorbidities among United States Adults with asthma and Their Association with Asthma Severity
Prevalence of Comorbidities among United States Adults with asthma and Their Association with Asthma Severity
AbstractIntroductionThe burden of comorbidities in asthma patients significantly affects management strategies and outcomes. This study aimed to analyze the prevalence and trends o...
Pediatric Difficult Airway Management: Assessment and Intervention
Pediatric Difficult Airway Management: Assessment and Intervention
Background: Pediatric airways exemplify the adage that children are not merely small adults. Their airway anatomical differences are markedly different than that of an adult system...
Epidermal mucus as a potential biological and biochemical matrix for fish health analysis
Epidermal mucus as a potential biological and biochemical matrix for fish health analysis
Fish reside in ecosystems teeming with pathogens, so their mucus has developed antimicrobial properties that help inhibit these pathogens. The fish's epidermal mucus serves as the ...