Urinary neutrophil gelatinase‐associated lipocalin predicted to contrast‐associated acute kidney injury after planned percutaneous coronary intervention in elderly patients

AbstractAimTo determine the proportion of contrast‐associated acute kidney injury (CA‐AKI) after percutaneous coronary intervention (PCI) and the predictive value of urine neutrophil gelatinase‐associated lipocalin (uNGAL) for CA‐AKI in elderly patients with chronic coronary artery disease.MethodsA total of 509 patients who had planned percutaneous coronary intervention (mean age was 63.58 ± 11.63 years and 63.3% of males) were divided into two groups: group 1 (n = 153; elderly patients) with ≥70 years old and group 2 (n = 356) with <70 years old. Urine NGAL was measured by the ELISA method. Clinical and laboratory data were collected on the day before intervention. CA‐AKI was defined based on Kidney Disease: Improving Global Outcomes criteria.ResultsThe ratio of CA‐AKI in group 1 was 23.5% which was higher than that of group 2 (8.7%) with a p‐value < 0.001. Urine NGAL level in group 1 was significantly higher than that of group 2 [31.3 (19.16–55.13) ng/ml vs. 19.86 (13.21–29.04) ng/ml, p < 0.001]. At a cut‐off value of 44.43 ng/ml, uNGAL had a predictive value for CA‐AKI in all patients (AUC = 0.977, p < 0.001). Especially at a cut‐off value of 44.14 ng/ml, uNGAL had a predictive value for CA‐AKI in elderly patients (AUC = 0.979, p < 0.001).ConclusionsThe rate of CA‐AKI after PCI in elderly patients was 23.5%. Urine NGAL before PCI had a good predictive value for CA‐AKI in elderly patients with chronic coronary artery disease.