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5′‐ UTRs and Regulation
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Abstract
The 5′ untranslated region consists of the leading part of a cellular messenger ribonucleic acid (mRNA) from the 5′ end to the translation start codon AUG. Precursor mRNA is posttranscriptionally modified by the removal of introns and by the addition at the 5′ end of a 7‐methyl‐guanylate cap structure, which has a crucial role in translation initiation and in regulating transcript stability. 5′‐UTRs as well as 3′‐UTRs, are deeply involved in regulation of gene expression through specific motifs that can affect mRNA stability, subcellular localization, nuclear export, tissue specificity and efficiency of translation.
Title: 5′‐
UTRs
and Regulation
Description:
Abstract
The 5′ untranslated region consists of the leading part of a cellular messenger ribonucleic acid (mRNA) from the 5′ end to the translation start codon AUG.
Precursor mRNA is posttranscriptionally modified by the removal of introns and by the addition at the 5′ end of a 7‐methyl‐guanylate cap structure, which has a crucial role in translation initiation and in regulating transcript stability.
5′‐UTRs as well as 3′‐UTRs, are deeply involved in regulation of gene expression through specific motifs that can affect mRNA stability, subcellular localization, nuclear export, tissue specificity and efficiency of translation.
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