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Acute Immune Response toMycobacterium massiliensein C57BL/6 and BALB/c Mice
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ABSTRACTMycobacterium massilienseis an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 106CFU of anM. massiliensestrain isolated from a nosocomial infection in Brazil. The results presented here show thatM. massilienseis virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by IL-12 in BALB/c mice.
Title: Acute Immune Response toMycobacterium massiliensein C57BL/6 and BALB/c Mice
Description:
ABSTRACTMycobacterium massilienseis an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery.
We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 106CFU of anM.
massiliensestrain isolated from a nosocomial infection in Brazil.
The results presented here show thatM.
massilienseis virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by IL-12 in BALB/c mice.
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