Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Lactate Dehydrogenase A as a Target of Cancer Therapy
View through CrossRef
Lactate dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate to lactate and on the contrary lactate to pyruvate. LDH is a tetramer consisting of two types of subunits M (LDHA) and H (LDHB). LDHA catalyzes the conversion of pyruvate to lactate, while LDHB converts lactate to pyruvate. LDHA increases its expression in cancer cells and is associated with cancer aggressiveness. Lactate that continues to increase gives the effect of an acidic microenvironment so that there is sufficient availability of oxygen for metabolism, which increases anaerobic glycolysis and decreases oxidative phosphorylation. Inhibition of LDHA can provide hope in cancer therapy because many studies have shown that inhibition of LDHA reduces cancer growth. This review will describe several cancer treatment approaches using LDH as a cancer therapy target until now.
Title: Lactate Dehydrogenase A as a Target of Cancer Therapy
Description:
Lactate dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate to lactate and on the contrary lactate to pyruvate.
LDH is a tetramer consisting of two types of subunits M (LDHA) and H (LDHB).
LDHA catalyzes the conversion of pyruvate to lactate, while LDHB converts lactate to pyruvate.
LDHA increases its expression in cancer cells and is associated with cancer aggressiveness.
Lactate that continues to increase gives the effect of an acidic microenvironment so that there is sufficient availability of oxygen for metabolism, which increases anaerobic glycolysis and decreases oxidative phosphorylation.
Inhibition of LDHA can provide hope in cancer therapy because many studies have shown that inhibition of LDHA reduces cancer growth.
This review will describe several cancer treatment approaches using LDH as a cancer therapy target until now.
Related Results
Distribution, organization and expression of genes concerned with anaerobic lactate-utilization in human intestinal bacteria
Distribution, organization and expression of genes concerned with anaerobic lactate-utilization in human intestinal bacteria
Abstract
Lactate accumulation in the human gut is linked to a range of deleterious health impacts. However, lactate is consumed and converted to ...
Lactate Administration Increases Skeletal Muscle Synthesis in Mice
Lactate Administration Increases Skeletal Muscle Synthesis in Mice
Purpose
Lactate, secreted by skeletal muscle during exercise, had been known as fatigue substance. However, several physiological roles of lactate have been rev...
Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria
Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria
Lactate accumulation in the human gut is linked to a range of deleterious health impacts. However, lactate is consumed and converted to the beneficial short-chain fatty acids butyr...
Mitochondrial disorders in neuromuscular pathology
Mitochondrial disorders in neuromuscular pathology
Introduction. With the advent of new drugs — analogues of mitochondrial metabolites, the widespread introduction into practice of research methods for assessing the function of mit...
Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling
Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling
Innate immune neutrophils provide the first line of host defense against bacterial infections. Neutrophils under steady state rely almost entirely on glycolysis and exhibit very lo...
Role of Lactate in the Regulation of Transcriptional Activity of Breast Cancer-Related Genes and Epithelial-to-Mesenchymal Transition Proteins: A Compassion of MCF7 and MDA-MB-231 Cancer Cell Lines
Role of Lactate in the Regulation of Transcriptional Activity of Breast Cancer-Related Genes and Epithelial-to-Mesenchymal Transition Proteins: A Compassion of MCF7 and MDA-MB-231 Cancer Cell Lines
ABSTRACTThe Warburg Effect is characterized by accelerated glycolytic metabolism and lactate production and under fully aerobic conditions is a hallmark of cancer cells. Recently, ...
Increased Lactate Can Promote Histone Lactylation in Failing Right Ventricular Cardiomyocytes in Pulmonary Arterial Hypertension
Increased Lactate Can Promote Histone Lactylation in Failing Right Ventricular Cardiomyocytes in Pulmonary Arterial Hypertension
Abstract
Background: Using a multimodal approach, we recently showed that, in pulmonary arterial hypertension (PAH), lactate is a key feature of altered cardiomyo...
POC Assessment of Combined Umbilical Arterial and Venous Lactate: A Potential Screening Test for Neonatal Acidosis [OP04-7D]
POC Assessment of Combined Umbilical Arterial and Venous Lactate: A Potential Screening Test for Neonatal Acidosis [OP04-7D]
INTRODUCTION:
Umbilical artery (UA) lactate and pH aid the diagnosis of neonatal acidosis. This study examines the relationship between point-of-care (POC) measurement ...