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Down Syndrome
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People with Down syndrome (trisomy 21) are distinguished by having an extra copy of chromosome 21. Chromosome 21 contains an estimated 562 genes, including 161 known to code for functional proteins, and at least 396 considered novel. Gene dosage imbalance is the primary mechanism, which results in the molecular, cellular, histological, and anatomical features characteristic of the condition. Throughout brain development, major neurobiological events go awry, resulting in a differently organized brain and characteristic developmental delays noted during infancy and the preschool years. The consequences of gene dosage imbalance continue to have repercussions on neurobiological function throughout childhood and adult life.
Title: Down Syndrome
Description:
People with Down syndrome (trisomy 21) are distinguished by having an extra copy of chromosome 21.
Chromosome 21 contains an estimated 562 genes, including 161 known to code for functional proteins, and at least 396 considered novel.
Gene dosage imbalance is the primary mechanism, which results in the molecular, cellular, histological, and anatomical features characteristic of the condition.
Throughout brain development, major neurobiological events go awry, resulting in a differently organized brain and characteristic developmental delays noted during infancy and the preschool years.
The consequences of gene dosage imbalance continue to have repercussions on neurobiological function throughout childhood and adult life.
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