Abstract 4147578: Temporal Trends in Stroke-related Mortality in Canada Over the Past 30 Years

Introduction: Stroke is among the leading global health burdens worldwide due to the resultant morbidity and mortality. Accordingly, thorough evaluation of the temporal trends in stroke-related mortality in Canada is mandatory to effectively tackle the associated global and socioeconomic burden. Research Question: Are there temporal trends in stroke-related mortality in Canada during the last 3 decades? Aim: To evaluate the temporal trends in stroke-related mortality in Canada over the past 3 decades. Methods: Mortality trends of stroke in Canada have been evaluated by initially retrieving data from Global Burden of Diseases 2019 database. JoinPoint Analysis software was utilized to calculate the Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC). Results: There was a total of 1,269,854 stroke-related death reported during the period of 1990-2019. There is an overall decline in stroke-related death, with females displaying a higher decline in mortality from 1990 to 2019 with AAPC of -1.00 (95%CI: - 1.04 to -0.96; p<0.001) than males (AAPC -0.68 95%CI: -0.73 to -0.62; p<0.001). Additionally. There is a declining mortality among all age groups, most significantly in the group of 50-74 years of age (AAPC -1.23, 95%CI: -1.31 to -1.15; p<0.001) followed by the 75 years and older age group (AAPC -1.20, 95%CI: -1.27 to -1.12; p<0.001), while the group of the 15-49 year old had the smallest decrease in mortality (AAPC - 0.97, 95%CI: -1.16 to -0.72; p<0.001). Conclusion: A noticeable decline in the stroke-related mortality across both genders and all age groups in Canada has been demonstrated across the past 30 years. Comparison of these trends with other international and global trends is warranted to identify the factors associated with this decline.