Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Zweifel Olefination for C-Glycosylation
View through CrossRef
Starting from glycal derivatives, the Zweifel olefination presents an elegant opportunity to access C-glycosides in a selective manner. a-Lithiation of D-glucal, L-rhamnal, D-xylal and L-arabinal scaffolds was employed as a starting point in the synthesis of corresponding unsaturated aryl-, heteroaryl- and alkenyl-C-glycosides. This provides a straightforward strategy towards pharmacorelevant gliflozins and other unreported rhamnal- and xylal-analogs.
American Chemical Society (ACS)
Title: Zweifel Olefination for C-Glycosylation
Description:
Starting from glycal derivatives, the Zweifel olefination presents an elegant opportunity to access C-glycosides in a selective manner.
a-Lithiation of D-glucal, L-rhamnal, D-xylal and L-arabinal scaffolds was employed as a starting point in the synthesis of corresponding unsaturated aryl-, heteroaryl- and alkenyl-C-glycosides.
This provides a straightforward strategy towards pharmacorelevant gliflozins and other unreported rhamnal- and xylal-analogs.
Related Results
Julia Olefination
Julia Olefination
AbstractThe multistep preparation of trans‐olefins involving the addition of phenylsulfonyl carbanion to aldehydes or ketones to form β‐hydroxysulfones, followed by the esterificat...
Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics
Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics
Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety. ...
The role of protein glycosylation in Alzheimer disease
The role of protein glycosylation in Alzheimer disease
Glycosylation is one of the most common, and the most complex, forms of post‐translational modification of proteins. This review serves to highlight the role of protein glycosylati...
Implications of aberrant glycosylation on age-related disease progression
Implications of aberrant glycosylation on age-related disease progression
Glycosylation, the enzymatic attachment of glycans to proteins, is a ubiquitous post-translational modification in eukaryotes, responsible for many essential physiological processe...
Effect of C-domain N-glycosylation and deletion on rat pancreaticα-amylase secretion and activity
Effect of C-domain N-glycosylation and deletion on rat pancreaticα-amylase secretion and activity
Even though all animal α-amylases include glycosylation sequons (Asn-Xaa-Thr/Ser) in their sequences, amylases purified from natural sources are not quantitatively glycosylated. Wh...
Transition-Metal-Free and Selective Deconstructive Carbonyl Olefination of α-Hydroxy Ketones: A Complementary Approach to Knoevenagel Reaction
Transition-Metal-Free and Selective Deconstructive Carbonyl Olefination of α-Hydroxy Ketones: A Complementary Approach to Knoevenagel Reaction
AbstractWhile the carbonyl olefination has been extensively studied and well documented, use of α-hydroxy ketones as precursors for the carbonyl olefination is not reported, till d...
Schmidt Glycosylation
Schmidt Glycosylation
Abstract
The Schmidt glycosylation is a Lewis acid‐catalyzed glycosylation using glycosyl trichloroacetimidate as the donor. Presently, it is one of the most...
Bioinformatics identification of potential protein glycosylation genes associated with glioma stem cell signature
Bioinformatics identification of potential protein glycosylation genes associated with glioma stem cell signature
Abstract
Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma (GBM), which is the most malignant form of glioma. The implications and underlying mechanis...