Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Creatine kinase isoenzymes of mitochondrial origin in human serum.
View through CrossRef
Abstract
We measured creatine kinase (EC 2.7.3.2) activity in 1009 serum samples from 538 patients in the intensive-care units of the University of Texas Medical Branch hospitals. Creatine kinase isoenzymes migrating cathodal to skeletal muscle creatine kinase (CK-MM) on cellulose acetate electrophoresis were found in sera from 14 of the 538 patients. Creatine kinase, lactate dehydrogenase (EC 1.1.1.27), aspartate aminotransferase (EC 2.6.1.1), and alanine aminotransferase (EC 2.6.1.2) activities were abnormally increased in these 14 patients. Liver lactate dehydrogenase isoenzyme (LDH5) and cardiac creatine kinase isoenzyme (CK-MB) were abnormally increased in 12 and eight of these patients, respectively. Ten of the 14 patients died during their hospital admission. We believe the creatine kinase isoenzymes that migrated cathodal to skeletal muscle creatine kinase (CK-MM) were of mitochondrial origin.
Title: Creatine kinase isoenzymes of mitochondrial origin in human serum.
Description:
Abstract
We measured creatine kinase (EC 2.
7.
3.
2) activity in 1009 serum samples from 538 patients in the intensive-care units of the University of Texas Medical Branch hospitals.
Creatine kinase isoenzymes migrating cathodal to skeletal muscle creatine kinase (CK-MM) on cellulose acetate electrophoresis were found in sera from 14 of the 538 patients.
Creatine kinase, lactate dehydrogenase (EC 1.
1.
1.
27), aspartate aminotransferase (EC 2.
6.
1.
1), and alanine aminotransferase (EC 2.
6.
1.
2) activities were abnormally increased in these 14 patients.
Liver lactate dehydrogenase isoenzyme (LDH5) and cardiac creatine kinase isoenzyme (CK-MB) were abnormally increased in 12 and eight of these patients, respectively.
Ten of the 14 patients died during their hospital admission.
We believe the creatine kinase isoenzymes that migrated cathodal to skeletal muscle creatine kinase (CK-MM) were of mitochondrial origin.
Related Results
Case report: One child with an autism spectrum disorder who had chronically elevated serum levels of CK and CK-MB
Case report: One child with an autism spectrum disorder who had chronically elevated serum levels of CK and CK-MB
Some patients with autism spectrum disorder (ASD) exhibit elevated serum creatine kinase levels, which are believed to be associated with mitochondrial dysfunction. Although a few ...
Myofibrillar interaction of cytosolic creatine kinase (CK) isoenzymes: allocation of N-terminal binding epitope in MM-CK and BB-CK
Myofibrillar interaction of cytosolic creatine kinase (CK) isoenzymes: allocation of N-terminal binding epitope in MM-CK and BB-CK
ABSTRACT
The molecular origin of the isoenzyme-specific interaction of cytosolic creatine kinase isoenzymes, muscle-type creatine kinase and brain-type creatine kina...
Creatine as a mitochondrial theranostic in predictive, preventive, and personalized medicine
Creatine as a mitochondrial theranostic in predictive, preventive, and personalized medicine
Abstract
Creatine, traditionally recognized for its role in skeletal muscle energy metabolism, is increasingly emerging as a mitochondria-targeted theranostic agent with ...
Creatine synthesis in piglets
Creatine synthesis in piglets
It has recently been shown that genetic defects in proteins involved in creatine synthesis or transport are associated with neurological problems in children; these include mental ...
CONTENT OF ANTIOXIDANT DEFENSE ENZYMES ISOZYMES IN REPRODUCTIVE ORGANS, EPIDIDYMAL SPERMS AND EJACULATES OF BOARS
CONTENT OF ANTIOXIDANT DEFENSE ENZYMES ISOZYMES IN REPRODUCTIVE ORGANS, EPIDIDYMAL SPERMS AND EJACULATES OF BOARS
The content of superoxide dismutase (SOD) and catalase (CAT) isoenzymes in reproductive organs and freshly obtained ejaculates of wild boars were studied. It was established that t...
Circulating CK-MB and CK-BB isoenzymes after prostate resection.
Circulating CK-MB and CK-BB isoenzymes after prostate resection.
Abstract
We studied the effect of prostate resection on serum creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) isoenzymes in 22 patients. Two hou...
Features of the lactate dehydrogenase isoenzymes spectrum in animal tissues and organs
Features of the lactate dehydrogenase isoenzymes spectrum in animal tissues and organs
Activity and content of lactate dehydrogenase (LDH) isoenzymes is one of the objective criteria for assessing oxidative metabolism in organs and tissues and the physiological state...
Effect of Oral Creatine Supplementation on Human Muscle GLUT4 Protein Content After Immobilization
Effect of Oral Creatine Supplementation on Human Muscle GLUT4 Protein Content After Immobilization
The purpose of this study was to investigate the effect of oral creatine supplementation on muscle GLUT4 protein content and total creatine and glycogen content during muscle disus...