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Fibrinolytic therapy
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Fibrinolytic agents are able to reopen blood vessels that are occluded by a fresh thrombus. Urokinase, streptokinase, and streptokinase derivatives were the first effective agents. Recombinant plasminogen activators became available and they are specific for thrombus-bound fibrin. Significant bleeding is the major side effect of fibrinolysis, a major hurdle for its use. The current era of mechanical reperfusion has made fibrinolytic therapy a niche treatment for acute arterial thrombosis such as ST elevation myocardial infarction and stroke. Only for pulmonary embolism with haemodynamic consequences and mechanical heart valve thrombosis may lytic therapy have a place in selected patients.
Title: Fibrinolytic therapy
Description:
Fibrinolytic agents are able to reopen blood vessels that are occluded by a fresh thrombus.
Urokinase, streptokinase, and streptokinase derivatives were the first effective agents.
Recombinant plasminogen activators became available and they are specific for thrombus-bound fibrin.
Significant bleeding is the major side effect of fibrinolysis, a major hurdle for its use.
The current era of mechanical reperfusion has made fibrinolytic therapy a niche treatment for acute arterial thrombosis such as ST elevation myocardial infarction and stroke.
Only for pulmonary embolism with haemodynamic consequences and mechanical heart valve thrombosis may lytic therapy have a place in selected patients.
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