Diagnostic Value of C-Reactive Protein and Total Leukocyte Count in Acute Appendicitis

Objective: To find the diagnostic value of C-Reactive Protein and Total Leukocyte Count in acute appendicitis. Study Design: Validation study. Place and Duration of Study: Department of Surgery, Combined Military Hospital, Bahawalpur Pakistan, from Oct 2022 to Sep 2023. Methodology: A total of 210 patients were included who underwent appendectomy. Total Leukocyte Count and C-Reactive Protein C-Reactive Protein were checked pre-operatively. Per operative findings, histopathology and duration of the start of symptoms were also noted. Results: Out of 210 patients, 127(60.47%) were male and 83(39.53%) were female. There was a significant difference (p-value <0.001) in an increase of Total Leukocyte Count and C-Reactive Protein with positive operative findings. When compared with histopathological findings both show a significant difference (p-value<0.001). As the duration of symptoms increased there was a statistically significant difference in the values of both Leukocyte Count and C-Reactive Protein (p-value<0.001). The sensitivity, specificity, positive predictive value, negative Predictive Value, and accuracy of Total Leukocyte Count were (75.39%), (78.95%), (97.30%), (24.19%), and (75.71%), and for C-Reactive Protein were (72.77%), (78.95%), (97.20%), (22.39%), and (73.33%). Conclusion: The results suggest that both C-Reactive Protein and Total Leukocyte Count have potential as diagnostic markers for acute appendicitis. The values of Both C-Reactive Protein and Total Leukocyte Count increase as the duration of symptoms increases.