The Association Between Retinal Vessel Abnormalities and H-type Hypertension

Abstract Introduction: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. Methods: Hypertensive patients were retrospectively enrolled in this study. According to serum homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension group. Retinal fundus photography was used to evaluate the diameter of retinal vessels and retinopathy. Univariate and multivariate regression were used to investigate difference of retinal vessel abnormalities between H-type hypertension and isolated hypertension patients. Results: A total of 191 hypertensive patients were included, of which 85 were isolated hypertension and 106 were H-type hypertension. H-type hypertension patients had a higher ratio of retinopathy(P=0.004) and higher degree of retinal arteriosclerosis (P=0.005). CRAE(P=0.002) and AVR(P=0.001) were smaller in H-type hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension were still risk factor of retinopathy(OR, 2.259; 95%CI, 1.165—4.378; P=0.016), CRAE (B=-5.669; 95%CI, -9.452—-1.886; P=0.004), and AVR(B=-0.023; 95%CI,-0.039—-0.007; P=0.005). Conclusion: H-type hypertension may aggravate retinal vessel abnormalities compared with isolated hypertension.