Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Identification and characterization of presenilin I‐467, I‐463 and I‐374
View through CrossRef
We cloned a novel isoform of presenilin I (presenilin I‐374) besides previously published presenilin I‐467 and I‐463 in human lymphocytes. Presenilin I‐463 was identical to presenilin I‐467 except a 12 bp nucleotides deletion in its amino terminal region. Another isoform, presenilin I‐374 was produced by an alternative splicing with an additional exon consisting of 92 bp nucleotides (exon 11), which resulted in the frame shift with a stop codon to generate a truncated presenilin consisting of 374 amino acids. The transcripts for presenilin I‐4671463 was ubiquitously detected while that for presenilin I‐374 was selectively detected in liver, spleen, kidney. Abnormal behavior of presenilin I on gel electrophoresis was found with affinity‐purified antibodies against presenilin I.
Title: Identification and characterization of presenilin I‐467, I‐463 and I‐374
Description:
We cloned a novel isoform of presenilin I (presenilin I‐374) besides previously published presenilin I‐467 and I‐463 in human lymphocytes.
Presenilin I‐463 was identical to presenilin I‐467 except a 12 bp nucleotides deletion in its amino terminal region.
Another isoform, presenilin I‐374 was produced by an alternative splicing with an additional exon consisting of 92 bp nucleotides (exon 11), which resulted in the frame shift with a stop codon to generate a truncated presenilin consisting of 374 amino acids.
The transcripts for presenilin I‐4671463 was ubiquitously detected while that for presenilin I‐374 was selectively detected in liver, spleen, kidney.
Abnormal behavior of presenilin I on gel electrophoresis was found with affinity‐purified antibodies against presenilin I.
Related Results
■ REVIEW : The Presenilins
■ REVIEW : The Presenilins
Presenilin-1 and presenilin-2 are highly homologous genes located on chromosomes 14 and 1, respectively, that have recently been linked to some cases of early-onset autosomal domin...
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
De-identifying government datasets:
De-identifying government datasets:
De-identification is a general term for any process of removing the association between a set of identifying data and the data subject. This document describes the use of de-identi...
Performance and feasibility of reactive surveillance and response strategies for malaria elimination in Vietnam: a mixed-methods study
Performance and feasibility of reactive surveillance and response strategies for malaria elimination in Vietnam: a mixed-methods study
Abstract
Background
To enhance malaria elimination, Vietnam adopted a Reactive Surveillance and Response (RASR) Strategy in which malaria case notif...
Seismic Mapping of Massive Dolomite Deposit Associated with Demise of MSC Salt Giant in Ionian Basin
Seismic Mapping of Massive Dolomite Deposit Associated with Demise of MSC Salt Giant in Ionian Basin
<p>The origin of massive dolomite deposits has been an enduring and challenging problem for carbonate sedimentologists since the initial recognition of dolomite as a ...
Towards A Cell Biology of Alzheimer’s Disease
Towards A Cell Biology of Alzheimer’s Disease
In many neurodegenerative disorders, including Alzheimer's Disease (AD), the dysfunction of multiple cell types causes neuronal cell death, but the precise cellular processes invol...
Presenilin‐2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
Presenilin‐2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
AbstractWe have previously shown that familial Alzheimer’s disease mutants of presenilin‐2 (PS2) and, to a lesser extent, of presenilin‐1 (PS1) lower the Ca2+ concentration of intr...
HIF-1α Inhibition Sensitized Pituitary Adenoma Cells to Temozolomide by Regulating Presenilin 1 Expression and Autophagy
HIF-1α Inhibition Sensitized Pituitary Adenoma Cells to Temozolomide by Regulating Presenilin 1 Expression and Autophagy
Pituitary adenomas usually develop temozolomide resistance, which could compromise the anticancer effects of temozolomide. Suppression of hypoxia-inducible factor 1α has been shown...