Prognostic Prediction, Immune Microenvironment, and Drug Resistance Value of Collagen Type I Alpha 1 Chain (COL1A1) in Pan-Cancer Analysis

Abstract Objective The protein encoded by collagen type I alpha 1 chain(COL1A1)is a component of the extracellular matrix, and critical for tumor microenvironments. However, it remains unclear that the expression level, prognostic prediction, and immunological value of COL1A1 in multiple cancers. Methods 4 profiles and 6 hub genes were found by bioinformatics analysis. We further analyzed one of the hub genes, the COL1A1. And, we comprehensively analyzed gene expression and genetic alteration patterns among 33 types of malignancies from The Cancer Genome Atlas(TCGA). Besides, we explored the correlation of COL1A1 with cancer prognosis, immune infiltrates, tumor mutational burden (TMB)/ microsatellite instability status (MSI), pathway and drug sensitivity analysis of co-expressed genes. Results COL1A1 was highly expressed and associated with poor prognosis in the majority of cancer. On the other hand, COL1A1 expression was closely related to high TMB in THYM, LAML, ACC, KICH, PRAD, and LGG. High MSI was observed in TGCT, MESO, PRAD, COAD, SARC, and CESC. In addition, COL1A1 was positively correlated with the abundance of CAFs, macrophages, and tumor-infiltrating lymphocytes. However, it was negatively correlated with CD8 + T cells mainly in CESC, HNSC-HPV+, and SKCM. Conclusion COL1A1 can serve as a prognostic and immunological biomarker in multiple cancers.