Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
FORMULATION AND EVALUATION OF PHYSOSTIGMINE-TRANSDERMAL PATCH
View through CrossRef
In present study transdermal drug delivery of Physostigmine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Among all the formulations P6 formulation was found to be best and shown 96.5% drug release in 12 hours. For P6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release.
South Asian Academic Publications
Title: FORMULATION AND EVALUATION OF PHYSOSTIGMINE-TRANSDERMAL PATCH
Description:
In present study transdermal drug delivery of Physostigmine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route.
Matrix type of transdermal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.
Transdermal patches were prepared by employing solvent casting method.
Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer.
Among all the formulations P6 formulation was found to be best and shown 96.
5% drug release in 12 hours.
For P6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release.
Related Results
Intermittent Transdermal Nitroglycerin Therapy
Intermittent Transdermal Nitroglycerin Therapy
Background
Intermittent transdermal nitroglycerin therapy is effective in the treatment of stable angina and prevents the development of tolerance. Previous investigati...
Transdermal drug delivery systems: Analysis of adhesion failure
Transdermal drug delivery systems: Analysis of adhesion failure
The most critical component of the TDDS is the adhesive, which is responsible for the safety, efficacy and quality of the patch. For drug delivery to successfully occur, the patch ...
Refining intra-patch connectivity measures in landscape fragmentation and connectivity indices
Refining intra-patch connectivity measures in landscape fragmentation and connectivity indices
Abstract
Context. Measuring intra-patch connectivity, i.e. the connectivity within a habitat patch, is important to evaluate landscape fragmentation and connectivity. Howev...
Reducing Computational Complexity in Vision Transformers Using Patch Slimming
Reducing Computational Complexity in Vision Transformers Using Patch Slimming
Vision Transformers (ViTs) have emerged as a dominant class of deep learning models for image recognition tasks, demonstrating superior performance compared to traditional Convolut...
Formulation, Development and Characterization of Transdermal Patches of Metformine Hydrochloride as Lοw Dοse Maintenance Therapy
Formulation, Development and Characterization of Transdermal Patches of Metformine Hydrochloride as Lοw Dοse Maintenance Therapy
The οbjective οf the prοpοsed study was tο develοp lοw dοse support treatment οf metformin hydrochloride in diabetic patients. The pοtassium brοmide pellet was mοunted in IR compar...
Polimer Semi-Sintetik Berbasis Karbopol, HPMC, dan Na-CMC untuk Patch Mukoadhesif
Polimer Semi-Sintetik Berbasis Karbopol, HPMC, dan Na-CMC untuk Patch Mukoadhesif
Abstract. Bukal mucoadhesive patches are an important innovation in drug delivery as they enable rapid drug absorption and bypass first-pass metabolism, thereby improving therapeut...
Genetic variation in patch time allocation in a parasitic wasp
Genetic variation in patch time allocation in a parasitic wasp
1.The intra‐patch experience acquired by foraging parasitoid females has often been considered to have a strong influence on their tendency to leave a patch, and thus on their tota...
Formulation and Evaluation Transdermal Patch of Aqueous Extract of Azadirachta indica A. Juss using Different Polymers
Formulation and Evaluation Transdermal Patch of Aqueous Extract of Azadirachta indica A. Juss using Different Polymers
The goal of the Novel Drug Delivery System is to deliver a therapeutic dose of drug to an appropriate place within the body quickly so that the desired drug concentration can be ma...